Antifungal Gap-Fill Exercise:  Fluconazole

 

Fill in all the gaps, then press "Check" to check your answers.
   amphotericin B      cryptococcal meningitis      CSF      cytochrome P450 drug      intrathecal      oral   
Fluconazole is noted, among azoles, for its good penetration. Its water solubility allows not only for i.v. administration but also accounts for good bioavailability by the route of administration. Drug-drug interactions are less common with fluconazole because it interacts less with the metabolizing system. It is the drug of choice for treating . I.V. fluconazole has been show to be equivalent to in management of candidemia in the ICU setting, assuming that the patient has normal white cell blood counts. Oral high-dose fluconazole may be often be an effective replacement for amphotericin B route of administration for treating .