Medical Pharmacology Chapter 38: Antiparasitic Agents

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Giardia Life Cycle
  • "Infection occurs by the ingestion of cysts in contaminated water or food. 

  • In the small intestine, excystation releases trophozoites that multiply by longitudinal binary fission. 

  • The trophozoites remain in the lumen of the proximal small bowel where they can be free or attached to the mucosa by a ventral sucking disk. 

  • Encystation occurs when the parasites transit toward the colon, and cysts are the stage found in normal (non diarrheal) feces. 

  •  The cysts are hardy, can survive several months in cold water, and are responsible for transmission. 

  • Because the cysts are infectious when passed in the stool or shortly afterward, person-to-person transmission is possible. 

  • While animals are infected with Giardia, their importance as a reservoir is unclear."

  • courtesy of the Division of Parasitic Diseases at the National Center for Infectious Diseases, Centers for Disease Control and Prevention

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