Antihypertensives: Practice Exam #1
Click on the correct answer.
 

1This antihypertensive drug is contraindicated in patients with bilateral renal artery stenosis:
clonidine (Catapres)
terazosin (Hytrin)
nifedipine (Procardia, Adalat)
captopril (Capoten)
metoprolol (Lopressor)

2Antihypertensive drug typically used in patients with severe hypertension and renal insufficiency; this agent produces significant fluid retention and hypertrichosis.
hydralazine (Apresoline)
methyldopa (Aldomet)
minoxidil (Loniten)
nitroprusside sodium (Nipride)
diltiazem (Cardiazem)

3The drug of choice in management of hypertensive crisis when continuously variable IV infusion is required.
lisinopril (Prinvivil, Zestril)
diazoxide (Hyperstat)
nifedipine (Procardia, Adalat)
nitroprusside sodium (Nipride)
metoprolol (Lopressor)

4A drug-induced lupus-like syndrome is associated with this antihypertensive drug
minoxidil (Loniten)
hydralazine (Apresoline)
diazoxide (Hyperstat)
nitroprusside sodium (Nipride)
acebutolol (Sectral)

5Tachycardia due to hydralazine administration would be blocked by:
bumetanide (Bumex)
fosinopril (Monopril)
mecamylamine (Inversine)
nifedipine (Procardia, Adalat)
minoxidil (Loniten)

6A diabetic patient is prescribed a new medication to control mild hypertension. The patient then becomes less aware of hypoglycemic symptoms. The antihypertensive drug was most probably:
phentolamine (Regitine)
atenolol (Tenormin)
enalapril (Vasotec) and
hydralazine (Apresoline)
prazosin (Minipress)

7Which drug would be least likely used in the initial pharmacological treatment of mild hypertension?
amlodipine (Norvasc)
metoprolol (Lopressor)
enalapril (Vasotec)
minoxidil (Loniten)
chlorothiazide (Diuril)

8Which antihypertensive drug would be contraindicated if the patient were taking tranylcypromine (Parnate)?
hydrochlorothiazide (HCTZ, Esidrix, HydroDIURIL)
diltiazem (Cardiazem)
guanethidine (Ismelin)
lisinopril (Prinvivil, Zestril)
labetalol (Trandate, Normodyne)

9Which drug would block the antihypertensive efficacy of guanadrel (Hylorel)?
buspirone (BuSpar)
lorazepam (Ativan)
imipramine (Tofranil)
propranolol (Inderal)
chlorothiazide (Diuril)

10Lisinopril belongs to which class of antihypertensive drugs?
centrally-acting sympatholytic
beta-adrenoceptor antagonist
angiotensin II receptor antagonist
beta-adrenoceptor agonist
angiotensin II converting enzyme inhibitor

11Most likely to be used for initial drug management of moderate hypertension
guanethidine (Ismelin)
nitroprusside sodium (Nipride)
minoxidil (Loniten)
nifedipine (Procardia, Adalat)
hydralazine (Apresoline)

12Antihypertensive agents -- side effect profile includes impaired glucose tolerance, hypokalemia, increased serum lipids and increased renin secretion:
methyldopa (Aldomet)
chlorothiazide (Diuril)
nifedipine (Procardia, Adalat)
nitroprusside sodium (Nipride)
diazoxide (Hyperstat)

13Effects of hydralazine (Apresoline):
increased renin levels
lupus-like syndrome
reflex bradycardia
hypertensive response if patient ingests food rich in tyramine
all of the above

14Mechanisms by which blood-pressure may be reduced:
reduced cardiac output
increased vagus nerve activity
decreased central sympathetic outflow
reduced angiotensin II levels
all the above

15Orthostatic hypotension:
minoxidil (Loniten)
imipramine (Tofranil)
hydralazine (Apresoline)
methyldopa (Aldomet)
all of the above

16Antihypertensive drug least likely to cause orthostatic hypotension:
minoxidil (Loniten)
enalapril (Vasotec)
guanethidine (Ismelin)
hydralazine (Apresoline)
terazosin (Hytrin)

17Vascular smooth muscle relaxation by means of calcium channel blockade:
hydralazine (Apresoline)
nitroprusside sodium (Nipride)
nifedipine (Procardia, Adalat)
captopril (Capoten)
phentolamine (Regitine)

18Protects against tachycardia caused by minoxidil (Loniten) administration:
prazosin (Minipress)
diltiazem (Cardiazem)
metoprolol (Lopressor)
losartin (Cozaar)
methyldopa (Aldomet)

19Mechanism of antihypertensive action:inhibition of peptidyl dipeptidase
metoprolol (Lopressor)
verapamil (Isoptin, Calan)
lisinopril (Prinvivil, Zestril)
diazoxide (Hyperstat)

20Antihypertensive agent that can produce a positive Coombs' test
clonidine (Catapres)
guanabenz (Wytensin)
guanfacine (Tenex)
methyldopa (Aldomet)
all the above