Disopyramide [di so peer' a mide]
(Class I Channel Blocker)
  •   electrophysiological effects similar to quinidine

  •  prescribed to maintain normal sinus rhythm in patients prone to atrial fibrillation and flutter and is also used to prevent ventricular fibrillation or tachycardia.

  •  adverse side-effect profile

  •   is different from qunidine's in that disopyramide is not an alpha-adrenergic receptor blocker but is anti-vagal.

  • depresses contractility which may lead to congestive heart failure

  •  can cause torsades de pointes, a ventricular arrhythmia

 
Disopyramide