Mexiletine[mex il' e teen]
(Class I, Sodium Channel Blocker)
  •  analog of lidocaine, but with reduced first-pass metabolism.

  •  used for treatment of ventricular arrhythmias.

  •  suitable for oral administration.

  •  similar electrophysiologically to lidocaine.

  • tremor and nausea are major dose-related adverse side effects.

  •  metabolized by the liver.

  •  Combination with quinidine may increase efficacy and diminish adverse effects.

Antiarrhythmic Drugs; Mexiletine