-
Antihypertensive effects
of propranolol are due to
-
(1) decreased myocardial
contractility and rate and
-
(2) to consequences of
decreased renin secretion. Both effects
occur as a consequence of beta-adrenoceptor blockade
-
Decreased renin levels lead
to decreases in circulating angiotensin
II and effects on aldosterone levels.
-
Propranolol is an example of
a non-selective β blocker,
antagonizing both β1 (cardiac) and β2 (extra-cardiac) sites.
-
β receptor
blockade causes decreased myocardial contractility, increases in
serum triglycerides and decreases in HDL cholesterol levels and
increases in bronchial smooth muscle tone.
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