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Medical Pharmacology:  Parkinson's Disease Practice Exam Questions

This is a self-grading exam. Answers are entered by clicking the button corresponding to your selection. The examination is scored by clicking 'Grade Test' at the bottom of the form. Correct answers and explanations are found through hyperlinks at the bottom of the page.



Question # 1 (Multiple Choice) Reason that dopamine itself is not used to treat in Parkinson's disease:

    A) too expensive
    B) the problem is cholinergic in nature
    C) dopamine does not cross the blood-brain barrier
    D) levodopa has a higher affinity for the D2 receptor

Question # 2 (Multiple Choice) Dominantly inherited disease: associated with progressive chorea and dementia; related to neurotransmitter imbalance

    A) Wilson's disease
    B) tardive dyskinesia
    C) Tourette's syndrome
    D) Huntington's disease
    E) Shy-Drager syndrome

Question # 3 (Multiple Choice) Antiviral drug found to have anti-Parkinson's properties:

    A) procyclidine
    B) pergolide
    C) amantadine
    D) levodopa
    E) reserpine

Question # 4 (True/False) Benefits of dopaminergicanti--Parkinson's drugs probably due to stimulation of D2 dopamine receptors

    A) true
    B) false

Question # 5 (Multiple Choice) Irregular, unpredictable, involuntary muscle contractions:

    A) athetosis
    B) dystonia
    C) tics
    D) chorea
    E) akinesia

Question # 6 (Multiple Choice) Dopamine agonist ergot derivative -- stimulates D1 & D2 receptors

    A) levodopa
    B) amantadine
    C) pergolide
    D) selegiline
    E) trihexyphenidyl

Question # 7 (Multiple Choice) Characterized by chronic, multiple tics:

    A) Parkinson's disease
    B) Wilson's disease
    C) Shy-Drager syndrome
    D) Tourette's syndrome
    E) all of the above

Question # 8 (Multiple Choice) Percentage of levodopa that enters the brain unaltered

    A) 1-3%
    B) 5-10%
    C) 15-30%
    D) > 50%

Question # 9 (Multiple Answer) Effective in managing essential tremor

    A) propranolol
    B) metoprolol
    C) primidone
    D) diazepam
    E) chlordiazepoxide

Question # 10 (Multiple Choice) First-line anti-Parkinson drug; also used to treat hyperprolactinemia at lower doses

    A) amantadine
    B) levodopa
    C) bromocriptine
    D) selegiline
    E) benztropine mesylate

Question # 11 (Multiple Choice) Carbidopa is useful in the management of Parkinson's disease because it is an:

    A) effective D2 agonist
    B) effective D2 antagonist
    C) effective peripheral decarboxylase inhibitor
    D) effective central decarboxylase inhibitor
    E) :effective competitor at the GABA receptor

Correct Answers

1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11






































Question # 1 (Multiple Choice) Reason that dopamine itself is not used to treat in Parkinson's disease:

Answer: (C) dopamine does not cross the blood-brain barrier

BACK







































Question # 2 (Multiple Choice) Dominantly inherited disease: associated with progressive chorea and dementia; related to neurotransmitter imbalance

Answer: (D) Huntington's disease

BACK







































Question # 3 (Multiple Choice) Antiviral drug found to have anti-Parkinson's properties:

Answer: (C) amantadine

Anti-Parkinson mechanism of action unclear; knack by affecting dopamine reuptake, synthesis, or release BACK







































Question # 4 (True/False) Benefits of dopaminergicanti--Parkinson's drugs probably due to stimulation of D2 dopamine receptors

Answer: True

BACK







































Question # 5 (Multiple Choice) Irregular, unpredictable, involuntary muscle contractions:

Answer: (D) chorea

chorea: may be hereditary, secondary to non--neurological disease; drug-induced BACK







































Question # 6 (Multiple Choice) Dopamine agonist ergot derivative -- stimulates D1 & D2 receptors

Answer: (C) pergolide

pergolide & bromocriptine are ergot alkaloid derivatives useful in treating Parkinson's disease BACK







































Question # 7 (Multiple Choice) Characterized by chronic, multiple tics:

Answer: (D) Tourette's syndrome

BACK







































Question # 8 (Multiple Choice) Percentage of levodopa that enters the brain unaltered

Answer: (A) 1-3%

most levodopa is metabolized extracerebrally BACK







































Question # 9 (Multiple Answer) Effective in managing essential tremor

(A) propranolol

(B) metoprolol

(C) primidone

probably a beta-adrenergic receptor dysfunction; anti-Parkinson agents, diazepam, chlordiazepoxide, mephenesin not useful BACK







































Question # 10 (Multiple Choice) First-line anti-Parkinson drug; also used to treat hyperprolactinemia at lower doses

Answer: (C) bromocriptine

ergot derivative; dopamine agonist, probably at D2 receptors BACK







































Question # 11 (Multiple Choice) Carbidopa is useful in the management of Parkinson's disease because it is an:

Answer: (C) effective peripheral decarboxylase inhibitor

BACK