Pharmacokinetic Problems Set

Click on the correct answer.



1 Consider the following information about drug X: D = 300 mg; T = 24 h; F = 0.70 (70% absorption);Vd = 40 L; half-life = 15 hours: What is the ke (elimination rate constant)?
0.133/hr
0.933/hr
0.046/hr
1.44/hr
0.693/hr

2 Consider the following information about drug X: D = 300 mg; T = 24 h; F = 0.70 (70% absorption);Vd = 40 L; half-life = 15 hours: What is the Css (concentration at steady-state) for drug X?
0.0462 ug/ml at 24 hours
4.7 ug/ml at 24 hours
2.4 ug/ml at 24 hours
6.76 ug/ml at 24 hours
4.73 mg/ml at 24 hours

3 Consider the following information about drug X: D = 300 mg; T =6 h; F = 0.70 (70% absorption);Vd = 40 L; half-life = 15 hours: What is the Css (concentration at steady-state) for drug X? (note dosing interval is now 6 hours)
4.7 ug/ml at 6 hours
2.4 ug/ml at 6 hours
19 ug/ml at 6 hours
9.5 ug/ml at 6 hours
none of the above

4 Consider the following information about drug X: D = 300 mg; T =12 h; F = 0.70 (70% absorption);Vd = 40 L; half-life = 15 hours: What is the Css (concentration at steady-state) for drug X? (note dosing interval is now 12 hours)
9.5 ug/ml at 12 hours
2.4 ug/ml at 12 hours
190 ug/ml at 12 hours
95 ug/ml at 12 hours
4.7 /ug/ml at 12 hours

5 Consider the following information about drug X: D = 300 mg; T =48 h; F = 0.70 (70% absorption);Vd = 40 L; half-life = 15 hours: What is the Css (concentration at steady-state) for drug X? (note dosing interval is now 48 hours)
16 ug/ml
4.7 ug/ml
19 ug/ml
2.4 ug/ml
9.5 ug/ml

6 Consider the following information about drug X: D =150mg; T =24 h; F = 0.70 (70% absorption);Vd = 40 L; half-life = 15 hours: What is the Css (concentration at steady-state) for drug X?
2.4 ug/ml
4.7 ug/ml
9.5 ug/ml
19 ug/ml
none of the above

7 Consider the following information about drug X: D = 600 mg; T =24 h; F = 0.70 (70% absorption);Vd = 40 L; half-life = 15 hours: What is the Css (concentration at steady-state) for drug X?
2.4 ug/ml
4.7 ug/ml
9.5 ug/ ml
19.0 ug/ml
1.2 ug/ml