Previous Page
Doxorubicin

  • Anthracyclines: Doxorubicin and Daunorubicin

    • IV administration; hepatic metabolism; biliary excretion; some urinary excretion; enterohepatic recirculation.
    • Among the most useful anticancer antibiotics
    • Mechanism of action:
      • DNA intercalation -- blocking synthesis of DNA and RNA; DNA strands scission -- by affecting topoisomerase II
      • Altering membrane fluidity and ion transport
      • Semiquinone free radical an oxygen radical generation (may be responsible for myocardial damage)
  • Clinical Uses:
    • Doxorubicin -- very important anticancer agent --
Carcinomas-Doxorubicin
 breast carcinoma ovarian carcinoma thyroid carcinoma
endometrial carcinoma testicular carcinoma lung carcinoma
 

Sarcomas-Doxorubicin
Ewing's sarcoma osteosarcoma rhabdomyosarcomas
 

Hematologic Cancers-Doxorubicin
acute leukemia multiple myeloma Hodgkin's disease non-Hodgkin's lymphoma
  •  Adjuvant therapy in: osteogenic sarcoma and breast cancer

Previous Page