- Mechanisms controlling body temperature
and know the basic mechanisms of local pain,
edema, fever and both acute and chronic
inflammation
 COX I versus COX
II
For
aspirin (acetylsalicylic acid), the following:
| Structure
Mechanisms of
anti-inflammatory, analgesic and antipyretic
effects
cyclooxygenase versus
lipoxygenase
Factors that influence
absorption and elimination
Hepatic metabolism
Dose-dependent pharmacokinetics
|
Contraindications
Side effects and
consequences of irreversible inhibition of
cyclooxygenase inhibition
Toxicity and treatment of
overdose
Adverse interactions with other
drugs (e.g., anti-coagulants, hypoglycemic drugs,
alcohol)
|
Basic
pharmacology and toxicology of NSAIDs
|
|
- ketoprofen
- naproxen
- piroxicam
|
- which NSAIDs need only be given once or
twice daily
- which NSAIDs can
be given with warfarin or tolbutamide
- rationale for
misoprostol as adjunct therapy with aspirin and
NSAIDs
- how
acetaminophen differs pharmacologically and
toxicologically from aspirin
- the metabolism
of acetaminophen, the role of cytochrome P450 in
activating acetaminophen to a reactive
metabolite, and the use of N-acetylcysteine in
treating acetaminophen hepatotoxicity
- Aspirin and NSAIDs in the treatment of
rheumatoid arthritis
- Basic
pharmacology and toxicology of slow-acting drugs
for treating rheumatoid arthritis
- Chloroquine
- Gold (aurothioglucose)
|
- D-Penicillamine
- Immunosuppressive drugs
- methotrexate
- cyclophosphamide
- cyclosporin
|
- IL-1 and TNF: targets of new treatments
of rheumatoid arthritis
- why
glucocorticoids (e.g., prednisone) have limited
use in the treatment of rheumatoid arthritis
- Cause and
pathophysiology of acute gouty arthritis and
chronic tophaceous gout
- different
mechanisms of action of allopurinol, colchicine,
indomethacin, probenecid and sulfinpyrazone in
the treatment of gout
- dangerous side
effects of colchicine
- indomethacin and
ibuprofen (NSAIDs other than aspirin) as
therapeutic options instead of colchicine to
treat the inflammation of acute gouty arthritis,
and why aspirin (except in high, doses) cannot be
used for this purpose
- why the
uricosuric agents, probenecid and sulfinpyrazone,
increase the risk of renal calculi, and what
steps are taken to reduce this risk
- potential
adverse drug interactions with allopurinol (e.g.,
with mercaptopurine)
|
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