Medical Pharmacology Chapter 21:  Histamine and Bradykinin Practice Questions

This is a self-grading exam. Answers are entered by clicking the button corresponding to your selection. The examination is scored by clicking 'Grade Test' at the bottom of the form. Correct answers are found through hyperlinks at the bottom of the page.



Question # 1 (True/False) Uterine sensitivity to ergot alkaloids increases as pregnancy progresses:

    A) true
    B) false

Question # 2 (Multiple Answer) Migraine: clinical presentations/characteristics

    A) usually unilaterall headache
    B) associated with stress
    C) equally common in women and men
    D) may be accompanied by a brief aura

Question # 3 (Multiple Choice) Vasoconstriction-- bradykinin

    A) arteriolar vascularl smooth muscle
    B) venular smooth muscle

Question # 4 (Multiple Choice) Less sedating:

    A) diphenhydramine (Benadryl)
    B) terfenadine (Seldane)
    C) about equal

Question # 5 (Multiple Choice) Most uterine selective -- agent of choice for obstetric use among ergot alkaloids

    A) ergotamine
    B) ergonovine
    C) methysergide (Sansert)

Question # 6 (Multiple Answer) Histamine receptor sites-- H1

    A) endothelium
    B) smooth muscle
    C) mast cell
    D) gastric mucosa

Question # 7 (Multiple Choice) More likely to be effective in treating an active migraine attack:

    A) sumatriptan (Imitrex)
    B) methysergide (Sansert)
    C) equally effective

Question # 8 (Multiple Choice) Drug treatment for hyperprolactinemia:

    A) bromocriptine (Parlodel)
    B) pergolide (Permax)
    C) both
    D) either

Question # 9 (True/False) Long-lasting vasospasm caused by ergotamine overdosage is reversible by alpha antagonists or serotonin antagonists:

    A) true
    B) false

Question # 10 (Multiple Choice) Ergot alkaloid -- antimigraine specificity mediated by these receptors:

    A) adrenergic
    B) cholinergic
    C) serotonergic
    D) dopaminergic

Question # 11 (Multiple Choice) Losartin (Cozaar): higher affinity for

    A) AT1 angiotensin receptors
    B) AT2 angiotensin receptors

Question # 12 (Multiple Choice) Enzyme catalyzing conversion of angiotensinogen to angiotensin I:

    A) serum cholinesterase
    B) aspartyl protease
    C) dopamine beta-hydroxylase
    D) phenylethanolamine N-methyltransferase

Question # 13 (True/False) Migraine -- drug treatment: alternative to ergotamine for acute migraine treatment but not recommended for patients with coronary vascular disease-- sumatriptan (Imitrex)

    A) true
    B) false

Question # 14 (Multiple Choice) Synthesis site of most circulatory renin:

    A) pulmonary
    B) liver
    C) kidney
    D) brain
    E) platelet

Question # 15 (True/False) Angiotensin II effects may cause vascular and myocardial hypertrophy

    A) true
    B) false

Question # 16 (Multiple Choice) CNS effects of ergot alkaloids:

    A) activation of pituitary prolactin secretion
    B) hallucinogenic effects
    C) both
    D) either

Question # 17 (Multiple Answer) Mechanism(s) of action for angiotensin II vasopressor response:

    A) CNS mediated
    B) ANS mediated
    C) direct arteriolar smooth muscle contraction

Question # 18 (True/False) Angiotensin II is a more potent vasopressor than norepinephrine

    A) true
    B) false

Question # 19 (Multiple Choice) Most commonly used drug for continuous migraine prophylaxis:

    A) methysergide (Sansert)
    B) ergonovine
    C) propranolol (Inderal)
    D) amitriptyline (Elavil, Endep)
    E) valproic acid

Question # 20 (Multiple Choice) Most common acute ergot toxicity:

    A) vasospasm
    B) retroperitoneal fibroplasia
    C) gastrointestinal upset -- e.g. vomiting
    D) subendocardial fibrosis

Question # 21 (Multiple Answer) Receptors affected by ergot alkaloids

    A) alpha-adrenergic
    B) dopamine receptors
    C) serotonin receptors

Question # 22 (Multiple Choice) Equal affinity for saralasin and angiotensin II:

    A) AT1 -type angiotensin receptor
    B) AT2 -type angiotensin receptor

Question # 23 (Multiple Answer) Sites of angiotensin II actions:

    A) vascular smooth muscle
    B) brain
    C) adrenal cortex
    D) kidney

Question # 24 (Multiple Choice) Reverses serious ergot alkaloid-mediated vasospastic reactions:

    A) nitroglycerin
    B) nitroprusside sodium (Nipride)
    C) both
    D) neither

Question # 25 (True/False) Major plasma kinin: bradykinin

    A) true
    B) false

Question # 26 (Multiple Answer) Likely to block renin secretion:

    A) clonidine (Catapres)
    B) isoproterenol
    C) methyldopa (Aldomet)
    D) metoprolol (Lopressor)

Question # 27 (Multiple Choice) Receptor type mediating urinary retention associated with first-generation H1 antagonists:

    A) adrenergic
    B) cholinergic
    C) serotonergic
    D) GABA-ergic

Question # 28 (Multiple Answer) Stimulates renin-angiotensin system:

    A) hydralazine (Apresoline)
    B) isoproterenol
    C) diuretics
    D) losartin (Cozaar)

Question # 29 (Multiple Choice) Common side effect of first-generation H1 antagonists:

    A) tachycardia
    B) pulmonary hypertension
    C) cholecystitis
    D) sedation
    E) intraperitoneal fibroplasia

Question # 30 (Multiple Choice) Fewer drug-drug interactions

    A) terfenadine (Seldane)
    B) fexofenadine (Allegra)
    C) about equal

Question # 31 (Multiple Answer) Associated with ergotamine -- drug treatment for migraine:

    A) best results obtained after attack begins
    B) ergotamine commonly combined with caffeine; caffeine promotes ergot alkaloid absorption
    C) excessive ergotamine may cause long-lasting, severe vasoconstriction

Question # 32 (True/False) Used to control late uterine bleeding,ergot derivatives are given before delivery

    A) true
    B) false

Question # 33 (Multiple Answer) clinical uses: H2 receptor blockade:

    A) peptic ulcer duodenal disease
    B) gastric ulcer
    C) gastroesophageal reflux disorder (erosive esophagitis)
    D) Zollinger-Ellison disease

Question # 34 (Multiple Choice) Angiotensin antagonist(s):

    A) losartin (Cozaar)
    B) valsartan (Diovan)
    C) both
    D) neither

Question # 35 (Multiple Choice) Vascular smooth muscle effects --ergotamine:

    A) vasodilatation
    B) vasoconstriction

Question # 36 (Multiple Choice) Cardiotoxicity in combining terfenadine (Seldane) with ketoconazole (Nizoral),

    A) characterized by Q-T (ECG) prolongation
    B) may cause ventricular arrhythmias; potentially fatal
    C) both
    D) either

Question # 37 (Multiple Answer) Effects of angiotensin II on the kidney:

    A) renovascular dilation
    B) enhanced sodium reabsorption at the proximal tubule
    C) renin secretion

Correct Answers

1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37






































Question # 1 (True/False) Uterine sensitivity to ergot alkaloids increases as pregnancy progresses:

Answer: True

BACK







































Question # 2 (Multiple Answer) Migraine: clinical presentations/characteristics

(A) usually unilaterall headache

(B) associated with stress

(D) may be accompanied by a brief aura

BACK







































Question # 3 (Multiple Choice) Vasoconstriction-- bradykinin

Answer: (B) venular smooth muscle

BACK







































Question # 4 (Multiple Choice) Less sedating:

Answer: (B) terfenadine (Seldane)

BACK







































Question # 5 (Multiple Choice) Most uterine selective -- agent of choice for obstetric use among ergot alkaloids

Answer: (B) ergonovine

BACK







































Question # 6 (Multiple Answer) Histamine receptor sites-- H1

(A) endothelium

(B) smooth muscle

BACK







































Question # 7 (Multiple Choice) More likely to be effective in treating an active migraine attack:

Answer: (A) sumatriptan (Imitrex)

BACK







































Question # 8 (Multiple Choice) Drug treatment for hyperprolactinemia:

Answer: (C) both

BACK







































Question # 9 (True/False) Long-lasting vasospasm caused by ergotamine overdosage is reversible by alpha antagonists or serotonin antagonists:

Answer: False

BACK







































Question # 10 (Multiple Choice) Ergot alkaloid -- antimigraine specificity mediated by these receptors:

Answer: (C) serotonergic

BACK







































Question # 11 (Multiple Choice) Losartin (Cozaar): higher affinity for

Answer: (A) AT1 angiotensin receptors

BACK







































Question # 12 (Multiple Choice) Enzyme catalyzing conversion of angiotensinogen to angiotensin I:

Answer: (B) aspartyl protease

BACK







































Question # 13 (True/False) Migraine -- drug treatment: alternative to ergotamine for acute migraine treatment but not recommended for patients with coronary vascular disease-- sumatriptan (Imitrex)

Answer: True

BACK







































Question # 14 (Multiple Choice) Synthesis site of most circulatory renin:

Answer: (C) kidney

BACK







































Question # 15 (True/False) Angiotensin II effects may cause vascular and myocardial hypertrophy

Answer: True

BACK







































Question # 16 (Multiple Choice) CNS effects of ergot alkaloids:

Answer: (B) hallucinogenic effects

BACK







































Question # 17 (Multiple Answer) Mechanism(s) of action for angiotensin II vasopressor response:

(A) CNS mediated

(B) ANS mediated

(C) direct arteriolar smooth muscle contraction

BACK







































Question # 18 (True/False) Angiotensin II is a more potent vasopressor than norepinephrine

Answer: True

BACK







































Question # 19 (Multiple Choice) Most commonly used drug for continuous migraine prophylaxis:

Answer: (C) propranolol (Inderal)

BACK







































Question # 20 (Multiple Choice) Most common acute ergot toxicity:

Answer: (C) gastrointestinal upset -- e.g. vomiting

BACK







































Question # 21 (Multiple Answer) Receptors affected by ergot alkaloids

(A) alpha-adrenergic

(B) dopamine receptors

(C) serotonin receptors

BACK







































Question # 22 (Multiple Choice) Equal affinity for saralasin and angiotensin II:

Answer: (B) AT2 -type angiotensin receptor

BACK







































Question # 23 (Multiple Answer) Sites of angiotensin II actions:

(A) vascular smooth muscle

(B) brain

(C) adrenal cortex

(D) kidney

BACK







































Question # 24 (Multiple Choice) Reverses serious ergot alkaloid-mediated vasospastic reactions:

Answer: (C) both

BACK







































Question # 25 (True/False) Major plasma kinin: bradykinin

Answer: True

BACK







































Question # 26 (Multiple Answer) Likely to block renin secretion:

(A) clonidine (Catapres)

(C) methyldopa (Aldomet)

(D) metoprolol (Lopressor)

BACK







































Question # 27 (Multiple Choice) Receptor type mediating urinary retention associated with first-generation H1 antagonists:

Answer: (B) cholinergic

BACK







































Question # 28 (Multiple Answer) Stimulates renin-angiotensin system:

(A) hydralazine (Apresoline)

(B) isoproterenol

(C) diuretics

BACK







































Question # 29 (Multiple Choice) Common side effect of first-generation H1 antagonists:

Answer: (D) sedation

BACK







































Question # 30 (Multiple Choice) Fewer drug-drug interactions

Answer: (B) fexofenadine (Allegra)

BACK







































Question # 31 (Multiple Answer) Associated with ergotamine -- drug treatment for migraine:

(B) ergotamine commonly combined with caffeine; caffeine promotes ergot alkaloid absorption

(C) excessive ergotamine may cause long-lasting, severe vasoconstriction

BACK