Medical Pharmacology Chapter 21:  Histamine

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Histamine

 

Introduction

Receptor Subtype

Localization

Receptor coupling

Antagonists (partially selective)

H1

Endothelium, brain, smooth muscle

Receptor activation causes and increased IP3, DAG (diacylglycerol)  production  

N/A

H2

Mast cells, gastric mucosa, cardiac muscle, brain

Receptor activation causes an  increase in cAMP production 

Ranitidine (Zantac), Cmetidine (Tagamet)

H3

Presynaptic: brain, mesenteric plexus (other neurons)

G protein coupled

N/A

Organ System Effects: Histamine

  1. Burkhalter, A, Julius, D.J. and Katzung, B. Histamine, Serotonin and the Ergot Alkaloids (Section IV. Drugs with Important Actions on Smooth Muscle), in Basic and Clinical Pharmacology, (Katzung, B. G., ed) Appleton-Lange, 1998, pp 261-286.

  2. Friedman, L. S. and Peterson, W.L. Peptic Ulcer and Related Disorders In Harrison's Principles of Internal Medicine 14th edition, (Isselbacher, K.J., and Braunwald, E., Wilson, J.D., Martin, J.B., Fauci, A.S. and Kasper, D.L., eds) McGraw-Hill, Inc (Health Professions Division), 1998, pp. 1597-1616.

 
 
 

 

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