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Medical Pharmacology:  Autacoid (e.g. Serotonin, Ergot Alkaloids) Practice Exam Questions

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Question # 1 (True/False) Uterine sensitivity to ergot alkaloids increases as pregnancy progresses:

    A) true
    B) false

Question # 2 (Multiple Answer) Migraine: clinical presentations/characteristics

    A) usually unilaterall headache
    B) associated with stress
    C) equally common in women and men
    D) may be accompanied by a brief aura

Question # 3 (Multiple Choice) Vasoconstriction-- bradykinin

    A) arteriolar vascularl smooth muscle
    B) venular smooth muscle

Question # 4 (Multiple Choice) Less sedating:

    A) diphenhydramine (Benadryl)
    B) terfenadine (Seldane)
    C) about equal

Question # 5 (Multiple Choice) Most uterine selective -- agent of choice for obstetric use among ergot alkaloids

    A) ergotamine
    B) ergonovine
    C) methysergide (Sansert)

Question # 6 (Multiple Answer) Histamine receptor sites-- H1

    A) endothelium
    B) smooth muscle
    C) mast cell
    D) gastric mucosa

Question # 7 (Multiple Choice) More likely to be effective in treating an active migraine attack:

    A) sumatriptan (Imitrex)
    B) methysergide (Sansert)
    C) equally effective

Question # 8 (Multiple Choice) Drug treatment for hyperprolactinemia:

    A) bromocriptine (Parlodel)
    B) pergolide (Permax)
    C) both
    D) either

Question # 9 (True/False) Long-lasting vasospasm caused by ergotamine overdosage is reversible by alpha antagonists or serotonin antagonists:

    A) true
    B) false

Question # 10 (Multiple Choice) Ergot alkaloid -- antimigraine specificity mediated by these receptors:

    A) adrenergic
    B) cholinergic
    C) serotonergic
    D) dopaminergic

Question # 11 (Multiple Choice) Losartin (Cozaar): higher affinity for

    A) AT1 angiotensin receptors
    B) AT2 angiotensin receptors

Question # 12 (Multiple Choice) Enzyme catalyzing conversion of angiotensinogen to angiotensin I:

    A) serum cholinesterase
    B) aspartyl protease
    C) dopamine beta-hydroxylase
    D) phenylethanolamine N-methyltransferase

Question # 13 (True/False) Migraine -- drug treatment: alternative to ergotamine for acute migraine treatment but not recommended for patients with coronary vascular disease-- sumatriptan (Imitrex)

    A) true
    B) false

Question # 14 (Multiple Choice) Synthesis site of most circulatory renin:

    A) pulmonary
    B) liver
    C) kidney
    D) brain
    E) platelet

Question # 15 (True/False) Angiotensin II effects may cause vascular and myocardial hypertrophy

    A) true
    B) false

Question # 16 (Multiple Choice) CNS effects of ergot alkaloids:

    A) activation of pituitary prolactin secretion
    B) hallucinogenic effects
    C) both
    D) either

Question # 17 (Multiple Answer) Mechanism(s) of action for angiotensin II vasopressor response:

    A) CNS mediated
    B) ANS mediated
    C) direct arteriolar smooth muscle contraction

Question # 18 (True/False) Angiotensin II is a more potent vasopressor than norepinephrine

    A) true
    B) false

Question # 19 (Multiple Choice) Most commonly used drug for continuous migraine prophylaxis:

    A) methysergide (Sansert)
    B) ergonovine
    C) propranolol (Inderal)
    D) amitriptyline (Elavil, Endep)
    E) valproic acid

Question # 20 (Multiple Choice) Most common acute ergot toxicity:

    A) vasospasm
    B) retroperitoneal fibroplasia
    C) gastrointestinal upset -- e.g. vomiting
    D) subendocardial fibrosis

Question # 21 (Multiple Answer) Receptors affected by ergot alkaloids

    A) alpha-adrenergic
    B) dopamine receptors
    C) serotonin receptors

Question # 22 (Multiple Choice) Equal affinity for saralasin and angiotensin II:

    A) AT1 -type angiotensin receptor
    B) AT2 -type angiotensin receptor

Question # 23 (Multiple Answer) Sites of angiotensin II actions:

    A) vascular smooth muscle
    B) brain
    C) adrenal cortex
    D) kidney

Question # 24 (Multiple Choice) Reverses serious ergot alkaloid-mediated vasospastic reactions:

    A) nitroglycerin
    B) nitroprusside sodium (Nipride)
    C) both
    D) neither

Question # 25 (True/False) Major plasma kinin: bradykinin

    A) true
    B) false

Question # 26 (Multiple Answer) Likely to block renin secretion:

    A) clonidine (Catapres)
    B) isoproterenol
    C) methyldopa (Aldomet)
    D) metoprolol (Lopressor)

Question # 27 (Multiple Choice) Receptor type mediating urinary retention associated with first-generation H1 antagonists:

    A) adrenergic
    B) cholinergic
    C) serotonergic
    D) GABA-ergic

Question # 28 (Multiple Answer) Stimulates renin-angiotensin system:

    A) hydralazine (Apresoline)
    B) isoproterenol
    C) diuretics
    D) losartin (Cozaar)

Question # 29 (Multiple Choice) Common side effect of first-generation H1 antagonists:

    A) tachycardia
    B) pulmonary hypertension
    C) cholecystitis
    D) sedation
    E) intraperitoneal fibroplasia

Question # 30 (Multiple Choice) Fewer drug-drug interactions

    A) terfenadine (Seldane)
    B) fexofenadine (Allegra)
    C) about equal

Question # 31 (Multiple Answer) Associated with ergotamine -- drug treatment for migraine:

    A) best results obtained after attack begins
    B) ergotamine commonly combined with caffeine; caffeine promotes ergot alkaloid absorption
    C) excessive ergotamine may cause long-lasting, severe vasoconstriction

Question # 32 (True/False) Used to control late uterine bleeding,ergot derivatives are given before delivery

    A) true
    B) false

Question # 33 (Multiple Answer) clinical uses: H2 receptor blockade:

    A) peptic ulcer duodenal disease
    B) gastric ulcer
    C) gastroesophageal reflux disorder (erosive esophagitis)
    D) Zollinger-Ellison disease

Question # 34 (Multiple Choice) Angiotensin antagonist(s):

    A) losartin (Cozaar)
    B) valsartan (Diovan)
    C) both
    D) neither

Question # 35 (Multiple Choice) Vascular smooth muscle effects --ergotamine:

    A) vasodilatation
    B) vasoconstriction

Question # 36 (Multiple Choice) Cardiotoxicity in combining terfenadine (Seldane) with ketoconazole (Nizoral),

    A) characterized by Q-T (ECG) prolongation
    B) may cause ventricular arrhythmias; potentially fatal
    C) both
    D) either

Question # 37 (Multiple Answer) Effects of angiotensin II on the kidney:

    A) renovascular dilation
    B) enhanced sodium reabsorption at the proximal tubule
    C) renin secretion

Correct Answers

1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37






































Question # 1 (True/False) Uterine sensitivity to ergot alkaloids increases as pregnancy progresses:

Answer: True

BACK







































Question # 2 (Multiple Answer) Migraine: clinical presentations/characteristics

(A) usually unilaterall headache

(B) associated with stress

(D) may be accompanied by a brief aura

BACK







































Question # 3 (Multiple Choice) Vasoconstriction-- bradykinin

Answer: (B) venular smooth muscle

BACK







































Question # 4 (Multiple Choice) Less sedating:

Answer: (B) terfenadine (Seldane)

BACK







































Question # 5 (Multiple Choice) Most uterine selective -- agent of choice for obstetric use among ergot alkaloids

Answer: (B) ergonovine

BACK







































Question # 6 (Multiple Answer) Histamine receptor sites-- H1

(A) endothelium

(B) smooth muscle

BACK







































Question # 7 (Multiple Choice) More likely to be effective in treating an active migraine attack:

Answer: (A) sumatriptan (Imitrex)

BACK







































Question # 8 (Multiple Choice) Drug treatment for hyperprolactinemia:

Answer: (C) both

BACK







































Question # 9 (True/False) Long-lasting vasospasm caused by ergotamine overdosage is reversible by alpha antagonists or serotonin antagonists:

Answer: False

BACK







































Question # 10 (Multiple Choice) Ergot alkaloid -- antimigraine specificity mediated by these receptors:

Answer: (C) serotonergic

BACK







































Question # 11 (Multiple Choice) Losartin (Cozaar): higher affinity for

Answer: (A) AT1 angiotensin receptors

BACK







































Question # 12 (Multiple Choice) Enzyme catalyzing conversion of angiotensinogen to angiotensin I:

Answer: (B) aspartyl protease

BACK







































Question # 13 (True/False) Migraine -- drug treatment: alternative to ergotamine for acute migraine treatment but not recommended for patients with coronary vascular disease-- sumatriptan (Imitrex)

Answer: True

BACK







































Question # 14 (Multiple Choice) Synthesis site of most circulatory renin:

Answer: (C) kidney

BACK







































Question # 15 (True/False) Angiotensin II effects may cause vascular and myocardial hypertrophy

Answer: True

BACK







































Question # 16 (Multiple Choice) CNS effects of ergot alkaloids:

Answer: (B) hallucinogenic effects

BACK







































Question # 17 (Multiple Answer) Mechanism(s) of action for angiotensin II vasopressor response:

(A) CNS mediated

(B) ANS mediated

(C) direct arteriolar smooth muscle contraction

BACK







































Question # 18 (True/False) Angiotensin II is a more potent vasopressor than norepinephrine

Answer: True

BACK







































Question # 19 (Multiple Choice) Most commonly used drug for continuous migraine prophylaxis:

Answer: (C) propranolol (Inderal)

BACK







































Question # 20 (Multiple Choice) Most common acute ergot toxicity:

Answer: (C) gastrointestinal upset -- e.g. vomiting

BACK







































Question # 21 (Multiple Answer) Receptors affected by ergot alkaloids

(A) alpha-adrenergic

(B) dopamine receptors

(C) serotonin receptors

BACK







































Question # 22 (Multiple Choice) Equal affinity for saralasin and angiotensin II:

Answer: (B) AT2 -type angiotensin receptor

BACK







































Question # 23 (Multiple Answer) Sites of angiotensin II actions:

(A) vascular smooth muscle

(B) brain

(C) adrenal cortex

(D) kidney

BACK







































Question # 24 (Multiple Choice) Reverses serious ergot alkaloid-mediated vasospastic reactions:

Answer: (C) both

BACK







































Question # 25 (True/False) Major plasma kinin: bradykinin

Answer: True

BACK







































Question # 26 (Multiple Answer) Likely to block renin secretion:

(A) clonidine (Catapres)

(C) methyldopa (Aldomet)

(D) metoprolol (Lopressor)

BACK







































Question # 27 (Multiple Choice) Receptor type mediating urinary retention associated with first-generation H1 antagonists:

Answer: (B) cholinergic

BACK







































Question # 28 (Multiple Answer) Stimulates renin-angiotensin system:

(A) hydralazine (Apresoline)

(B) isoproterenol

(C) diuretics

BACK







































Question # 29 (Multiple Choice) Common side effect of first-generation H1 antagonists:

Answer: (D) sedation

BACK







































Question # 30 (Multiple Choice) Fewer drug-drug interactions

Answer: (B) fexofenadine (Allegra)

BACK







































Question # 31 (Multiple Answer) Associated with ergotamine -- drug treatment for migraine:

(B) ergotamine commonly combined with caffeine; caffeine promotes ergot alkaloid absorption

(C) excessive ergotamine may cause long-lasting, severe vasoconstriction

BACK