Anesthesia Pharmacology Chapter
6: Autonomic (ANS) Pharmacology
Practice Questions
Click on the correct answer.
Immediate biosynthetic precursor of epinephrine:
- isoproterenol
- doapmine
- metaraminol
- norepinephrine
- L-DOPA
The magnitude of the cardiovascular response to norepinephrine is increased by cocaine because:
- cocaine increases conversion of norepinephrine to phenylephrine
- cocaine inhibits norepinephrine reuptake
- cocaine decreases N.E. metabolism by MAO
- cocaine increases N.E. receptor number
- cocaine decreases cholinergic receptor number
Increases both magnitude of the blood pressure increase due to phenylephrine and the heart rate decrease due to methacholine:
- timolol (Blocadren)
- mecamylamine (Inversine)
- clonidine (Catapres)
- atropine
- nitroprusside sodium (Nipride)
Drug causes pupillar dilation with no effect on accommodation:
- pilocarpine (Pilocar)
- atropine
- phenoxybenzamine (Dibenzyline)
- neostigmine (Prostigmin)
- phentolamine (Regitine)
Prevents blood pressure reduction seen with isoproterenol (Isuprel):
- atropine
- esmolol (Brevibloc)
- propranolol (Inderal)
- phentolamine (Regitine)
- phenylephrine (Neo-Synephrine)
Physiological effects associated with isoproterenol (Isuprel):
- increased peripheral resistance
- increased GI motility
- increased blood glucose
- decreased heart rate
- bronchoconstriction
Albuterol (Ventolin,Proventil):
- significant heart rate increase
- decreases myocardial contractility
- alpha adrenoceptor antagonist
- bronchodilation
- by I.V. injection only
Therapeutic use of esmolol (Brevibloc):
- bronchial asthma
- positive inotrope in CHF
- antiarrhythmic drug
- renal vasodilator
- antihypertensive
Isoproterenol (Isuprel): cardiopulmonary effects:
- increases peripheral resistance
- positive inotropism
- positive chronotropism
- A & C
- B & C
Beta-2 selective agonist:
- metaproterenol (Alupent)
- epinephrine
- phenylephrine (Neo-Synephrine)
- phentolamine (Regitine)
- labetalol (Trandate, Normodyne)