Anesthesia Pharmacology Chapter 14:  
General Anesthesia Practice Questions
 
 
-  Inhalational anesthetic effects on circulation will be influenced by: -   presence of heart disease
-   control ventilation vs. spontaneous breathing
-   presence of cardioactive drugs
-   A & C
-   A, B & C
 
- Inhalational agents--influence on circulatory systems: -   limited effect on myocardial contractility
-   affects peripheral vascular smooth muscle tone
-   changes autonomic nervous system activity
-   B & C
-   A, B & C
 
- Mean arterial pressure (MAP): inhalational agents -- -   dose-dependent decreases in MAP (healthy volunteers)
-   reduced MAP decrease compared to that observed with surgical stimulation
-   Mechanism of halothane (Fluothane)-mediated BP reduction: reduced systemic vascular resistance
-   A & C
-   B & C
 
- Mechanism BP reduction: isoflurane (Forane), desflurane (Suprane), sevoflurane (Sevorane, Ultane): -   decreased heart rate
-   decreased myocardial contractility
-   decreased systemic vascular resistance
-   decreased cardiac output
 
- Least likely to produce a change in systemic blood pressure: -   isoflurane (Forane)
-   enflurane (Ethrane)
-   nitrous oxide
-   halothane (Fluothane)
-    sevoflurane (Sevorane, Ultane)
 
- Reduction in mean arterial pressure following volatile anesthetic administration due to: -   direct pharmacological effects
-   reduced sympathetic activation cause by preoperative anxiety
-   both
-   neither
 
- Inhalational agent least likely to increase heart rate in healthy individuals -   isoflurane (Forane)
-   halothane (Fluothane)
-   desflurane (Suprane)
-   sevoflurane (Sevorane, Ultane)
 
- Isoflurane (Forane)-mediated increase in heart rate prevented by preoperative (just before induction) administration of: -   atropine
-   fentanyl (Sublimaze)
-   morphine
-   B & C
-   A, B & C
 
- Isoflurane (Forane) and blood pressure: -   neonates: increase blood-pressure, increased heart rate
-   elderly patients: reduced heart rate responses
-   younger patients: reduced heart rate
 
- Inhalational agent most likely to cause dose-dependent decrease in cardiac output {normal volunteer} -   desflurane (Suprane)
-   isoflurane (Forane)
-   halothane (Fluothane)
 
- Inhalational agent least likely to affect systemic vascular resistance in normal volunteers -   isoflurane (Forane)
-   halothane (Fluothane)
-   desflurane (Suprane)
-   sevoflurane (Sevorane, Ultane)
 
- Mechanism(s) of isoflurane (Forane)-mediated reduction in systemic vascular resistance: -   increased cutaneous blood flow
-   increased skeletal muscle blood flow
-   both
-   neither
 
- Administration of a volatile anesthetic for longer than five hours results in the recovery from cardiac depressing effects: -   true
-   false