Biotransformation

Anesthesia Pharmacology Chapter 2: Pharmacokinetics Practice Questions

Choose the correct answer for each question.

1 / 5

Drug biotransformation:
1. mainly, but not exclusively in the liver
2. products are usually less biologically active
3. biotransformation products can be toxic
4. A & B
5. A, B & C
Drug mixed-function oxidase (p450) mainly localized:
1. mitochondrial fraction
2. cell membranes
3. golgi bodies
4. microsomal fraction
5. nucleolus
Most drugs are oxidized in the:
1. smooth endoplasmic reticulum
2. rough endoplasmic reticulum
3. smooth and rough about equally
4. nucleus
5. none of the above
Primary site for drug metabolism:
1. stomach
2. small intestine
3. kidney
4. muscle
5. liver
Cytochrome-P450 INDEPENDENT oxidation
1. amine oxidase
2. epoxidation
3. N-oxidation
4. S-oxidation
5. deamination