Anesthesia Pharmacology Practice Questions: Antiarrhythmic Drugs

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Which one(s) of the following statements about lidocaine pharmacology and therapeutics is/are correct?
1. Administration of lidocaine 12 patients with suspected myocardial infarction decreased the likelihood of ventricular fibrillation in these patients.
2. Patients receiving lidocaine due to suspected myocardial infarction had a reduced likelihood of survival to hospital discharge.
3. Both
4. neither
Lidocaine is considered the agent of choice for both terminating ventricular tachycardia and making ventricular fibrillation following cardioversion less likely-in the context of acute myocardial ischemia.
1. True
2. False
Lidocaine may be conveniently administered orally making this route of administration both therapeutically useful and facilitating patient compliance.
1. True
2. False
Lidocaine acting as an antiarrhythmic agent and classified as subgroup 1B, acts by blockade of this cardiac ion channel:
1. Potassium channel
2. Calcium channel
3. Sodium-channel
4. Chloride channel
Lidocaine is viewed as one of the least cardiotoxic agents belonging to the sodium-channel blocker class.
1. True
2. False
Which one(s) of the following lidocaine adverse effects are considered common.
1. Paresthesias
2. Tremor
3. Lightheadedness
4. Hearing disturbance
5. All of the above
Lidocaine ion-channel blockade:
1. Activated sodium channels
2. Inactivated sodium channels
3. Both
4. Neither
Choose the correct statement(s) concerning lidocaine electrophysiological cardiac effects.
1. Lidocaine decreases slope of face4 depolarization and changes threshold thus decreasing automaticity
2. Action potential duration following lidocaine is typically either reduced or not affected.
3. Following lidocaine, the PR interval or the QRS interval duration is not significantly affected.
4. A & B
5. A, B & C
Administration of a large IV lidocaine dose administered rapidlymay cause which one(s) of the following adverse effects?
1. Seizure
2. Tremor
3. Dysarthria
4. All of the above
Lidocaine is routinely administered to all patients and coronary care units to protect against ventricular arrhythmias.
1. True
2. False