Anesthesia Pharmacology: Neuromuscular Junction
Blocker Practice Questions
Click on the correct answer.
1 / 10
The prototypical depolarizing-type neuromuscular blocking drug:
D-tubocurarine
Succinylcholine
Neuromuscular blockade reversal agent.
Sugammadex
Naloxone
Both
Neither
Cisatracurium is more clinically advantageous compared atracurium and as a result has replaced atracurium in practice.
True
False
Succinylcholine, an example of a depolarizing neuromuscular blocker, exhibits longer duration compared to acetylcholine mainly due to which one(s) of the following?
Tighter binding to the acetylcholine receptor
Resistance to inactivation by acetylcholinesterase
Compared to atricurium, cisatracurium is:
More dependent on the liver for inactivation.
More likely to cause histamine release.
Both
Neither
Phase I blockade could be potentiated by which one(s) of the following?
Edrophonium
Donepezil
Both
Neither
Muscle cell changes associated with prolonged depolarization include:
Reduced potassium
Increased sodium
Increased chloride
Increased calcium
Over time and with increasing succinylcholine concentrations, neuromuscular blockade may transition from a depolarizing, phase I block to a non-depolarizing phase II block.
True
False
Neuromuscular blockade due to depolarization induced by agents such as succinylcholine is initially described as a phase I block.
True
False
Botulinum toxin which may be used to manage ocular blepharospasm as well as control other muscle spasms block neuromuscular transmission mainly through inhibition of acetylcholine release.