Anesthesia Pharmacology Chapter 26: Renal Pharmacology Practice Questions

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Concerning the Na⁺-Cl^- symporter, choose the correct statement(s) from the following:
1. The Na⁺-Cl^- symporter is inhibited by thiazide diuretics.
2. The kidney is the primary site of expression of the Na⁺-Cl^- importer.
3. The Na⁺-Cl^- importer is associated with the distal collecting tubule epithelial cells apical membrane.
4. A & B
5. B & C
6. A & C
7. A, B & C
Aldosterone is a regulator of the Na⁺-Cl^- symporter.
1. True
2. False
Na⁺-Cl^- symporter mutation can result in an inherited hypokalemic alkalosis (Gitelman syndrome)
1. True
2. False
This agent is the only thiazide available for parenteral administration.
1. Chlorothalidone
2. Chlorothiazide
Thiazide pharmacology:
1. Thiazides are secreted in the proximal tubule by the organic acid secretory system.
2. Thiazides compete with uric acid secretion by competing with the organic acid secretory system.
3. Both
4. Neither
Thiazides (due to competition with the organic acid secretory system) may reduce uric acid secretion and elevate serum uric acid.
1. True
2. False
Thiazide diuretic administration(chronic) increase Ca²⁺ reabsorption and as a result:
1. Appear to slightly reduce the occurrence of osteoporotic fractures
2. Possibly useful in some cases in preventing calcium-containing renal stones resulting from hypercalciuria.
3. Both
4. Neither
Therapeutic use/uses of thiazide diuretics include which one(s) of the following?
1. Congestive heart failure (CHF)
2. Hepatic cirrhosis
3. Nephrotic syndrome
4. A & B
5. B & C
6. A & C
7. A, B & C
Treatment of hypertension is a major indication for thiazide diuretic therapeutic use.
1. True
2. False
Nephrogenic diabetes insipidus is a major indication for administration of thiazide diuretics.
1. True
2. False