DNA Gyrase Inhibitors

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*Ciprofloxacin (Cipro) & Ofloxacin (Floxin):inhibit gram negative cocci and bacilli: Enterobacteriaceae, Pseudomonas, Neisseria, Haemophilus Campylobacter; Staphylococci and streptococci are inhibited; Legionella, Chlamydia, M. tuberculosis, M avium are inhibited;Anaerobes: generally resistant

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Chambers, H.F. and Jawetz, E.Sulfonamides,Trimethoprim, and Quinolones,in Basic and Clinical Pharmacology,(Katzung, B. G., ed) Appleton-Lange, 1998, p. 765-767.