Medical Pharmacology: Antifungal Drug Practice Questions

Itraconazole (Sporanox and others):
1. Oral as well as IV routes of administration available.
2. Drug absorption (oral) increase by lower gastric pH and food.
3. Both
4. Neither
Example/examples of drug-drug interactions associated with itraconazole:
1. Reduced itraconazole bioavailability when used in combination with rifamycins such as rifabutin(Mycobutin), rifapentine (Priftin), rifampin (Rifadin).
2. Itraconazole administration substantially affects mammalian steroid synthesis.
3. Both
4. Neither
Itraconazole administered using the oral formulation (oral liquid, for example) employ cyclodextran as the carrier which enhances both bioavailability and solubility.
1. True
2. False
Itraconazole, comparable to ketoconazole, effectively penetrates into cerebrospinal fluid (CSF).
1. True
2. False
Itraconazole is considered in azole of choice in treating fungal infection due to which one/ones of the following?
1. Histoplasma
2. Blastomyces
3. Sporothrix
4. A & B
5. B & C
6. A & C
7. A, B & C
Azole of choice for treating Aspergillus species
1. Voriconazole (Vfend)
2. Itraconazole
3. Both
4. Neither
Itraconazole: frequently used in treating:
1. Dermatophytoses
2. Onchomycosis
3. Both
4. Either
Itraconazole (a triazole):
1. Similar Corticosteroid suppression as noted with ketoconazole.
2. Reduced antifungal spectrum compared to ketoconazole
3. Both
4. Neither
Itraconazole frequently employed:
1. In the treatment of invasive mold infections
2. As prophylaxis in preventing mold infections in certain patient populations. One population consists of patients exhibiting chronic granulomatous disease (CGD).
3. Both
4. Neither