|
| 1 | May precipitate acute asthma: |
|
|
|
exercise |
|
|
|
aspirin |
|
|
|
respiratory infection |
|
|
|
A, B, C |
|
|
|
|
|
| 2 | Some asthmatic patients exhibit aspirin sensitivity (and sensitivity to other NSAIDS). Daily administration of aspirin causes desensitization not only to aspirin also to other NSAIDS. This phenomenon is: |
|
|
|
the placebo effect |
|
|
|
cross-tolerance |
|
|
|
efficacy |
|
|
|
potency |
|
|
|
|
|
| 3 | A thirty-eight year old asthmatic who has been using beta adrenergic agonists for several years began to experience arrhythmias, premature atrial contractions. In order to suppress the arrhythmias, high-dose metoprolol therapy was started. Suggest a likely consequence: |
|
|
|
The cardioselective beta-blocker, metoprolol, alleviated the arrhythmia and did not affect the patient's asthma symptoms |
|
|
|
Since metoprolol is a beta agonist, the patient's arrhythmias worsened, but symptoms of asthma improved. |
|
|
|
The expiratory component of the patient's flow/volume curve was shortened. |
|
|
|
Metoprolol increased airway obstruction, worsening the patient's asthma, but improved the cardiac rhythm disorder. |
|
|
|
|
|
| 4 | Anti-asthma agent that acts in part by activating pulmonary beta-receptors thus increasing cAMP |
|
|
|
ipratropium |
|
|
|
terbutaline |
|
|
|
cromolyn |
|
|
|
methoxamine |
|
|
|
|
|
| 5 | An asthmatic is prescribed an adrenergic agent. After administration, the drug makes the patient tachycardiac and nervous. This drug was probably: |
|
|
|
albuterol |
|
|
|
isoproterenol |
|
|
|
terbutaline |
|
|
|
A & C |
|
|
|
|
|
| 6 | V/Q (ventilation/perfusion) mismatching which occurs in severe asthma results in hypoxemia. Terbutaline inhalation inproves the V/Q ratio. Why? |
|
|
|
Increased cardiac output increases pulmonary artery perfusion pressure in the lung |
|
|
|
Pulmonary vasodilation improves V/Q mismatching |
|
|
|
Bronchiolar relaxation improves ventilation. |
|
|
|
Actually, it is the use of supplimental oxygen that is more important than terbutaline. |
|
|
|
|
|
| 7 | Correct drug:property combination |
|
|
|
theophylline: hepatic oxidation and demethylation |
|
|
|
albuterol: beta2 adrenergic blocker |
|
|
|
ipratropium bromide: well-absorbed quaternary anticholinergic; associated with dry mouth |
|
|
|
Beclomethasone: enhances release of chemical mediators of bronchospasm which diminishes effectiveness of beta-2 adrenergic agonists. |
|
|
|
|
|
| 8 | Corticosteroids and the treatment of asthma: |
|
|
|
Corticosteroids relax smooth muscle |
|
|
|
Corticosteroids inhibit the inflammatory response. |
|
|
|
Corticosteroids reduce patient responsiveness to beta agonists |
|
|
|
In acute asthma, corticosteroids increase airway obstruction; therefore corticosteroids should only be used for chronic treatment. |
|
|
|
|
|
| 9 | Phosphodiesterase-inhibitor used in asthma therapy: |
|
|
|
ipratropium bromide |
|
|
|
aminophylline |
|
|
|
metaproterenol |
|
|
|
cyclosporine |
|
|
|
|
|
| 10 | Prophylactic antiasthmatic drug probably acts by preventing release of bronchoconstrictive mediators from mast cells: |
|
|
|
beclomethasone |
|
|
|
cromolyn |
|
|
|
metaproterenol |
|
|
|
albuterol |
|
|
|
|
|