Used in patients with ventricular
tachycardia or fibrillation resistant to
treatment with other drugs.
Effective inhibitor of abnormal automaticity.
Blocks sodium and potassium channels and prolongs
action potential duration.
Most serious adverse effect seen in
long-term therapy is a rapidly progressive
pulmonary fibrosis which may be fatal
Potent inhibitor of hepatic metabolism or
renal elimination of many drugs.
Warfarin, quinidine, procainamide and
digoxin are examples of drugs which may require
dosage reduction during amiodarone administration.