Prazosin, terazosin, and doxazosin reduce
arteriolar resistance and increase venous
capacitance as a consequence of alpha1 adrenergic
receptor blockade. The short-term increase in
heart rate and plasma renin levels do not persist
although the vasodilation continues.
Renal blood flow is maintained.
Retention of salt and water occurs.
Alpha1-adrenergic receptor blockers
reduce plasma triglycerides, total and
LDL-cholesterol, and increase HDL-cholesterol.