Sotalol is a nonselective
beta-adrenergic receptor antagonist that also
blocks potassium currents.
Sotalol prolongs action
potential duration, decreases automaticity, slows
impulse transmission through the AV node and
prolongs AV nodal refractoriness.
It is used in management of ventricular
tachyarrhythmias and is also used in treatment of
Antiarrhythmic effects are due both to
beta-adrenergic receptor and potassium channel
Normally, sympathetic drive results in
increased in Ca2+
Increased sympathetic tone also
increases phase 4 depolarization (heart rate goes
up), and increases DAD (delayed afterdepolarizations) and EAD (early
afterdepolarization) mediated arrhythmias.
effects are blocked by beta-adrenergic receptor