Medical Pharmacology Practice Questions: Anti-Depressant Drugs

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Which one(s) of the following antidepressant medications act mainly as an antagonist at the 5-HT2 receptor?
1. Trazodone
2. Chlorpheniramine
3. Nefazodone
4. Desipramine
5. A & B
6. A & C
7. B & C
8. A, B, C, D
Currently, the most common clinical use of trazodone is in the management of treatment-resistant depression.
1. True
2. False
This 5-HT2 serotonin receptor subtype inhibitor has been associated with hepatotoxicity, necessitating an FDA blackbox warning.
1. Nefazodone
2. Trazodone
3. Both
4. Neither
This agent acts as a receptor antagonist at the 5-HT3, 5-HT7 and 5-HT1D receptors and is a partial agonist at the 5-HT1B receptor and as an agonist at the 5-HT1A receptor.
1. Trazodone
2. Olanzapine
3. Vortioxetine
4. Mirtazapine
Example(s) of (an) anti-depressive agent/agents not typically associated with sexual effects.
1. Mirtazapine
2. Bupropion
3. Both
4. Neither
Vilazodone (Vibyrd) is an antidepressant agent which binds substantially to the serotonin transporter but only to a small degree to the norepinephrine and dopamine transporter.
1. True
2. False
The cytochrome P450 isoform CYP2D6 participates in the metabolism of SSRIs and SSRIs and themselves inhibit CYP2D6.
1. True
2. False
The therapeutic efficacy of tamoxifen, an estrogen antagonist useful in managing breast cancer, may be reduced upon concurrent administration of SSRIs.
1. True
2. False
Venlafaxine (Effexor) dosage requires reduction in patients with hepatic or renal impairment.
1. True
2. False
More likely to cause significant cardiovascular side effects:
1. Tricyclic antidepressants (TCAs)
2. Selective serotonin reuptake inhibitors (SSRIs)
3. Both equally likely to cause significant cardiovascular side effects