Medical Pharmacology Practice Exam Questions: Sedative-Hypnotic Drugs

Benzodiazepine antagonist:
1. diazepam (Valium)
2. naltrexone (ReVia)
3. flumazenil (Romazicon)
4. propranolol (Inderal)
5. pralidoxime (Protopam)
Shortest-acting benzodiazepine:
1. diazepam (Valium) (including metabolites)
2. lorazepam (Ativan) (including metabolites)
3. triazolam (Halcion) (including metabolites)
4. clonazepam (Klonopin) (including metabolites)
5. chlordiazepoxide (Librium) (including metabolites)
Benzodizepine action is associated with this neurotransmitter system:
1. cholinergic
2. adrenergic
3. glycine
4. glutamate
5. GABA
Benzodiazepine especially effective in managing panic disorder:
1. triazolam (Halcion)
2. flurazepam (Dalmane)
3. flumazenil (Romazicon)
4. alprazolam (Xanax)
5. thiopental (Pentothal)
Probably acts by binding to a component of the GABA receptor-coupled chloride channel, prolonging the duration of channel open state when the receptor is exposed to GABA:
1. chlordiazepoxide (Librium)
2. pentobarbital (Nembutal)
3. fentanyl (Sublimaze)
4. imipramine (Tofranil)
5. doxepin (Sinequan)
Petit mal and myoclonic seizures:
1. phenytoin (Dilantin)
2. clonazepam (Klonopin)
3. primidone (Mysoline)
4. triazolam (Halcion)
5. phenobarbital (Luminal)
Effective in managing acute ethanol withdrawal:
1. buspirone (BuSpar)
2. chlorpromazine (Thorazine)
3. amantidine (Symmetrel)
4. diazepam (Valium)
5. tranylcypromine (Parnate)
Barbiturates: lipid solubility and ionization:
1. lipid insoluble; weak base
2. lipid insoluble; weak acid
3. lipid soluble; weak acid
4. lipid soluble; weak base
Rapid anesthetic-induction agent;i.v. route of administration:
1. pentobarbital (Nembutal)
2. thiopental (Pentothal)
3. ethosuximide (Zarontin)
4. lorazepam (Ativan)
5. chloral hydrate (Noctec)
CNS depressant(s):
1. paraldehyde
2. pentobarbital (Nembutal)
3. lorazepam (Ativan)
4. B & C
5. A, B & C
Not classified as a CNS depressant, but causes significant sedation:
1. triazolam (Halcion)
2. imipramine (Tofranil)
3. phenobarbital (Luminal)
4. ethanol
5. flumazenil (Romazicon)
Anxiolytic: Serotonin-1A receptor sites--
1. flurazepam (Dalmane)
2. chloral hydrate (Noctec)
3. buspirone (BuSpar)
4. paraldehyde
5. meprobamate
Chronic use increases liver microsomal enzyme activity and increases urine production by inhibiting ADH.
1. phenobarbital (Luminal)
2. ethanol
3. triazolam (Halcion)
4. B & C
5. A, B & C
Tolerance and physical dependence not observed with this anxiolytic:
1. lorazepam (Ativan)
2. chloral hydrate (Noctec)
3. buspirone (BuSpar)
4. paraldehyde
5. meprobamate
Duration of barbiturate action mainly depends on:
1. rate of hepatic metabolism
2. excretion rate from renal and/or pulmonary systems
3. lipid solubility and time to distribute throughout the body
4. pharmacogenetic differents between patients