First Generation Cephalosporins
  • Rarely drug of choice
  • Very active against gram-positive cocci; not active against methicillin-resistant isolates of staphylococci.
  • Excretion by glomerular filtration and tubular secretion; may be block by probenecid
Chambers, H.F., Hadley, W. K. and Jawetz, E. Introduction to Antimicrobial Agents in Basic and Clinical Pharmacology, (Katzung, B. G., ed) Appleton-Lange, 1998, pp. 732-733.