Generally, more active
against gram-negative microbes (except
cefoperazone) and ability of some agents to
traverse the blood brain barrier.
Active against Citrobacter,
Serratia marcescens and Providencia
and ß-lactamase producing Haemophilus
and Neisseria.
Third
generation cephalosporins are effective in
treating a large variety of infections resistant
to many other drugs.
Ceftriaxone
(Rocephin) and and cefixime (Suprax) are first-line antibiotics for
treating gonorrhea.
Third
generation agents cross the blood brain barrier
and are effective in treating menningitis--caused
by pneumococci, meningococci, H.
influenzae and susceptible gram
negative rods (not by Listeria monocytogenes)
Ceftriaxone
(Rocephin) and cefotaxime (Claforan) most
active cephalosporins against
penicillin-resistant pneumococci.
Third generation agents may not be
effective in treating menningitis caused by
highly penicillin-resistant strains and treatment
may require addition of vancomycin (Vancocin) or rifampin (Rimactane)
and
Chambers, H.F., Hadley, W. K. and
Jawetz, E. Introduction to Antimicrobial Agents in Basic
and Clinical Pharmacology, (Katzung, B. G., ed)
Appleton-Lange, 1998, pp. 734-735.
Generally, more active
against gram-negative microbes (except
cefoperazone) and ability of some agents to
traverse the blood brain barrier.
Ceftriaxone
(Rocephin) and and cefixime (Suprax) are first-line antibiotics for
treating gonorrhea.
Third generation agents may not be
effective in treating menningitis caused by
highly penicillin-resistant strains and treatment
may require addition of vancomycin (Vancocin) or rifampin (Rimactane)
and