Chemotherapy Practice Questions: Set 1
Multiple-choice quiz
 
1Mechanism of cellular resistance to polyfunctional alkylating drugs:
decreased DNA repair capability
reduced production of glutathione
increased permeability to the drug
none of the above
2Does not have direct vesicant effects:
mechlorethamine (Mustargen)
carmustine (BNCU,BiCNU)
cyclophosphamide (Cytoxan)
A & B
3Polyfunctional alkylating agent used specifically for chronic myeloid leukemia:
cyclophosphamide (Cytoxan)
busulfan (Myleran)
thiopeta (Thioplex)
dacarbazine (DTIC)
4Major toxicity of alkylating drugs:
alopecia
myelosuppression
renal damage
hepatic failure
5Most useful alkylating drug currently available:
melphalan (Alkeran)
cyclophosphamide (Cytoxan)
lomustine (CCNU,CeeNU)
thiopeta (Thioplex)
6Most common route of administration for melphalan (Alkeran):
oral
iv
7Most common route of administration for cyclophosphamide (Cytoxan):
iv
oral
8Nitrosourea with minimal bone-marrow suppression and effective in treating pancreatic, islet cell carcinoma.
lomustine (CCNU,CeeNU)
carmustine (BNCU,BiCNU)
streptozocin (Zanosar)
procarbazine (Matulane)
9Used in combination with vinblastine and bleomycin: a major advance in treating nonseminomatous testicular cancer:
altretamine (Hexalen)
cisplatin (Platinol)
procarbazine (Matulane)
methotrexate
10Little effect on the bone marrow: can cause significant renal dysfunction and sometimes acoustic nerve dysfunction.
methotrexate
cisplatin (Platinol)
lomustine (CCNU,CeeNU)
A & C
11Anticancer drug that is also used to treat psoriasis and rheumatoid arthritis:
mercaptomurine (6-MP)
methotrexate
procarbazine (Matulane)
allopurinol (Zyloprim, Purinol)
12Combination of allopurinol with this anticancer drug can cause an increase in toxicity:
6-thioguanine
flurouracil (5-FU)
6-mercaptopurine
azatadine (Optimine)
13Recommended for treating hairy cell leukemia
methotrexate
cladribine (Leustatin)
vinblastine (Velban)
cytarabine (ara-C)