Antifungal Drugs
Click on the correct answer
1
Antifungal polyene macrolide that preferentially binds to fungal ergosterol which alters cellular permeability.
ketoconazole
amphotericin B
flucytosine
grisefulvin
clotrimazole
2
An azole most commonly used for topical treatment of candidiasis:
amphotericin B
clotrimazole
griseofulvin
flucytosine
none of the above
3
Polyene macrolide only used topically, due to systemic toxicity; active against most Candida species--most commonly used for suppression of local candidal infection.
miconazole
terbinafine
nystatin
fluconazole
flucytosine
4
Of ketoconazole, itraconazole, and fluconazole--most likely to cause increased arrhythmogenic effects of astemizole or terphidine
ketoconazole
itraconazole
fluconazole
5
Inhibition of fungal squalene epoxidase is this antifungal drug's mechanism of action:
ketoconazole
fluconazole
terbinafine
nystatin
A & B
6
More serious adverse effects: itraconazole (azole) or flucytosine (pyrimidine analogue)
flucytosine
itraconazole
7
Most potent of the presently available anti-fungal azoles:
fluconazole
itraconazole
ketoconazole
8
Azole most likely to get into the cerebral spinal fluid (CSF):
ketoconazole
itraconazole
fluconazole
9
Given by i.v. administration, the drug of choice for nearly all life-threatening mycotic infections--usually used as the initial induction regimen
ketoconazole
itraconazole
flucytosine
amphotericin B
nystatin
10
Topical allylamine(s) used for treating tinea cruris and tinea corporis:
terbinafine
naftifine
both
neither