Giardia Clinical Features/Laboratory Diagnosis
  • Clinical Features:
    • "The spectrum varies from asymptomatic carriage to severe diarrhea and malabsorption. 
    • Acute giardiasis develops after an incubation period of 5 to 6 days and usually lasts 1 to 3 weeks.  
    • Symptoms include;
      • diarrhea
      • abdominal pain
      • bloating
      • nausea
      • vomiting. 
    • In chronic giardiasis the symptoms are recurrent and malabsorption and debilitation may occur."
  • Laboratory Diagnosis:
    • "Giardiasis is diagnosed by the identification of cysts or trophozoites in the feces, using direct mounts as well as concentration procedures. 
    • Repeated samplings may be necessary. 
    • In addition, samples of duodenal fluid (e.g., Enterotest) or duodenal biopsy may demonstrate trophozoites. 
    • Alternate methods for detection include antigen detection tests by enzyme immunoassays, and detection of parasites by immunofluorescence. 
      • Both methods are available in commercial kits."
  • Treatment:
    • The Medical Letter recommends metronidazole (Flagyl) as the drug of choice, with tinidazole, furazolidone, and paromomycin as alternatives.