Clinical cases, organized by discipline
Depression and Bipolar Disorder: antidepressant, mood-stabilizer, and antipsychotic selection and management
Anxiety, OCD-Related, and Trauma-Related Disorders: anxiolytic, SSRI-dosing, augmentation, and PTSD pharmacotherapy across the full anxiety-spectrum volume
Schizophrenia Spectrum and Other Psychotic Disorders: clozapine initiation and rechallenge, long-acting injectables, treatment-resistant illness, catatonia, and antipsychotic dosing and side-effect management
Neurocognitive Disorders, Sleep-Wake Disorders, and Substance-Related and Addictive Disorders: Alzheimer's pharmacotherapy, delirium management, insomnia, narcolepsy, restless legs syndrome, obstructive sleep apnea, and alcohol/opioid/stimulant/tobacco/cannabis use disorder pharmacotherapy
Neurodevelopmental Disorders and Disruptive, Impulse-Control, and Conduct Disorders: ADHD, autism spectrum disorder, Tourette's, intellectual disability, and aggression/impulse-control pharmacotherapy
Dissociative Disorders and Somatic Symptom Disorders: depersonalization/derealization, dissociative identity disorder, somatic symptom and illness anxiety disorders, conversion disorder, and factitious disorder pharmacotherapy
Personality Disorders and Forensic Psychiatry: borderline/schizotypal/antisocial/avoidant personality pharmacotherapy, competency restoration, involuntary medication authority, and correctional psychiatric pharmacology
Elimination and Feeding/Eating Disorders: desmopressin and imipramine for enuresis, SSRI evidence in anorexia, bupropion's bulimia contraindication, binge eating disorder pharmacotherapy, and refeeding syndrome
Epilepsy and Episodic Disorders, and Neuromuscular Diseases: AED selection, status epilepticus, ALS, myasthenia gravis, GBS/CIDP, muscular dystrophy, and spasticity pharmacotherapy
Vascular Neurology, Movement Disorders, and Demyelinating Diseases: stroke thrombolysis, anticoagulation timing, Parkinson's pharmacotherapy, essential tremor, dystonia, and MS/NMOSD disease-modifying therapy
Seven topics complete: Genetic-Developmental, Behavioral Neurology, Headache-Pain, Psychiatric Disorders, Neuroinfectious Disease, Brain-Spinal Trauma, and Ophth-Otologic pharmacology
Five topics complete: metabolic-toxin, Kleine-Levin prophylaxis, glioma/craniotomy, autoimmune/paraneoplastic neurology, and POTS pharmacology
Two topics complete: Diabetes Mellitus/Hypoglycemia and Calcium & Bone, spanning metformin and GLP-1/SGLT2i therapy, hypoglycemia management, osteoporosis sequencing, and parathyroid and calcium disorders
Two topics complete: Thyroid and Lipids/Obesity/Nutrition, spanning levothyroxine dosing, hyperthyroidism therapy, statin and GLP-1/GIP obesity pharmacotherapy, and nutrition support in critical illness
Two topics complete: Adrenal and Pituitary, spanning insufficiency replacement, pheochromocytoma and Cushing's syndrome, acromegaly and prolactinoma therapy, and hypopituitarism replacement
Two topics complete: Female Reproduction and Male Reproduction, spanning PCOS therapy, menopausal and fertility decisions, TRT initiation and formulation, male infertility, and Klinefelter/Kallmann syndrome
Liver: MASH and viral hepatitis pharmacotherapy, alcohol-associated and autoimmune liver disease, cirrhosis complications, transplant immunosuppression, and hepatocellular carcinoma
Stomach/Duodenum and Esophagus: H. pylori eradication, gastroparesis, eosinophilic esophagitis, GERD, Barrett's esophagus, and achalasia
Colon and Small Intestine: IBD biologics and JAK inhibitors, C. difficile management, short bowel syndrome, and refractory celiac disease
Pancreas and Biliary Tract: cholangiocarcinoma, pancreatitis, gallstones, SOD, and post-transplant biliary complications
Two topics complete: Hematologic Neoplastic Disorders and Cellular Therapy, spanning TKI and JAK-inhibitor selection, CAR-T and bispecific sequencing, conditioning intensity, and GVHD prophylaxis and treatment
Three topics complete: Coagulation, Hematopoietic System, and Transfusion Medicine, spanning anticoagulant selection and reversal, anemia workup, hemoglobinopathy therapy, transfusion thresholds, and massive transfusion protocols
Two topics complete: Bacterial Disease and Fungi, spanning antibiotic and antifungal selection, dosing, and duration across bacteremia, C. difficile recurrence, tuberculosis, invasive aspergillosis, candidemia and Candida auris, and the endemic mycoses
Two topics complete: Viral Diseases and HIV, spanning antiviral and antiretroviral selection, dosing, and duration across influenza and COVID-19, CMV and other post-transplant viral infections, herpes zoster and HSV, ART timing and resistance-guided salvage therapy, and PrEP/PEP
Three topics complete: Immunocompromised Host, Antimicrobial Therapy, and Internal Medicine and Non-Infectious Syndromes, spanning infection risk in immunocompromising conditions, PK/PD and stewardship decisions, and the infection-mimic boundary in autoinflammatory and rheumatologic disease
Three topics complete: Travel and Tropical Medicine, Infection Prevention and Control, and Vaccinations, spanning malaria and tropical disease, surgical prophylaxis, decolonization, post-exposure chemoprophylaxis, and vaccine safety and sequencing decisions
Three topics complete: Chronic Kidney Disease, Acute Kidney Injury and ICU Nephrology, and Calcium, Phosphorus, and Magnesium Disorders and Stones, spanning RAAS inhibitor and SGLT2 inhibitor management, anemia correction, vasopressor and fluid choice in critical illness, CRRT anticoagulation and dosing, phosphate binder and calcimimetic selection, and stone-specific medical therapy
Two topics complete: Glomerular and Vascular Disorders and Kidney Transplantation, spanning glomerular disease and renal vasculitis, thrombotic microangiopathies, renovascular disease, immunosuppression selection, calcineurin-inhibitor conversion strategy, transplant infection prevention, and antibody-mediated rejection management
Two topics complete: Obstructive Lung Disease and Sleep Medicine, Neuromuscular, and Skeletal, spanning biologic selection in severe asthma and COPD, GLP-1/GIP therapy in sleep apnea and obesity hypoventilation syndrome, adaptive servo-ventilation contraindication, and ALS respiratory decline
Two topics complete: Critical Care Medicine and Vascular Diseases, spanning neuromuscular blockade and corticosteroid strategy in ARDS/septic shock, ECMO anticoagulation, sotatercept positioning in PAH, reperfusion escalation in PE, and riociguat/BPA sequencing in CTEPH
Three topics complete: Infections, Diffuse Parenchymal Lung Disease, and Neoplasia, spanning nontuberculous mycobacterial lung disease treatment, antifibrotic therapy in IPF and progressive pulmonary fibrosis, connective-tissue-disease-associated ILD, bronchiectasis/aspiration pneumonia decisions, lung cancer targeted-therapy sequencing, and paraneoplastic syndrome management
Three topics complete: Rheumatoid Arthritis, Crystal-Induced Arthropathies, and Spondyloarthritis, spanning conventional and biologic DMARD sequencing, JAK inhibitor risk stratification, allopurinol/febuxostat and pegloticase selection under renal constraints, CPPD management, and biologic selection across axial and peripheral spondyloarthritis under comorbidity constraints
Three topics complete: Other Rheumatic and Connective Tissue Disorders, Lupus Erythematosus, and Vasculitides, spanning stem-cell transplant eligibility and digital-ulcer therapy in systemic sclerosis, biologic selection and pregnancy-related management in SLE, and steroid-sparing therapy across giant cell arteritis and other vasculitides
Four topics complete: Nonarticular and Regional Musculoskeletal Disorders, Osteoarthritis, Infections and Related Arthritides, and Nonrheumatic Systemic Disorders, spanning fibromyalgia/CRPS/OA pharmacotherapy, infection-related immunosuppression and antibiotic decisions, and steroid-sparing therapy in systemic disorders with joint or muscle involvement
Two topics complete: Breast Cancer and Gastrointestinal Cancer, spanning HER2-targeted therapy de-escalation and escalation, extended adjuvant endocrine therapy, monarchE and KATHERINE eligibility edge cases, and colorectal, gastric, hepatobiliary, pancreatic, and neuroendocrine biomarker and regimen-duration decisions
Three topics complete: Hematologic Neoplasms, Genitourinary Cancer, and Thoracic Cancer, spanning FLT3/IDH1/KMT2A-targeted AML therapy, CML/CLL sequencing, MRD-threshold and maintenance decisions, myeloma regimen intensity, germ cell/prostate/renal cell/urothelial cancer pharmacology, and driver-mutation-targeted NSCLC, SCLC, mesothelioma, and thymoma therapy at the edge of trial-enrolled populations
Four topics complete: Palliative Care/Survivorship/Oncologic Complications, Skin Cancer/Sarcomas/Unknown Primary Site, Head/Neck/Thyroid/CNS Malignancies, and Gynecologic Cancer, spanning oncologic emergencies, treatment-toxicity management, melanoma/basal/squamous cell carcinoma and sarcoma pharmacology, glioma/CNS lymphoma/thyroid cancer therapy selection, and ovarian/cervical/endometrial cancer maintenance and sequencing decisions
One topic complete: Adult Cardiac Anesthesiology, spanning induction and hemodynamic management in structural and coronary disease, coagulation and blood-product decisions after bypass, vasoplegia and inotrope selection, perioperative antiplatelet/anticoagulant timing, and postoperative rhythm, sedation, and glycemic management
Two topics complete: Critical Care Medicine and Neurocritical Care, spanning malignant hyperthermia, LAST, and neuromuscular-blockade reversal, perioperative anaphylaxis and massive transfusion, osmotic therapy and status epilepticus management, sympathetic storming and post-arrest sedation, and antithrombotic timing after intracranial hemorrhage
Three topics complete: Pain Medicine, Pediatric Anesthesiology, and Hospice and Palliative Medicine, spanning perioperative buprenorphine management, repeated-anesthesia neurotoxicity, medical aid in dying protocol selection, palliative sedation and terminal delirium, refractory dyspnea and death rattle, and palliative-care integration timing
Three topics complete: General Urology, Endourology, and Calculous Disease, spanning 5-alpha-reductase inhibitor and alpha-blocker selection for BPH, PSA interpretation, tranexamic acid before PCNL, periprocedural antithrombotic management, medical expulsive therapy, febuxostat after CARES, and metabolic stone-prevention pharmacology
Three topics complete: Female Urology/URPS, Neurourology/Urodynamics, and Andrology, spanning first-line overactive bladder therapy, duloxetine for stress incontinence, neurogenic detrusor overactivity and onabotulinumtoxinA dosing, autonomic dysreflexia prophylaxis, exogenous testosterone alternatives with fertility plans, and testosterone therapy after prostate cancer
Four topics complete: Urologic Oncology, Pediatric Urology, Infectious Disease (Urologic), and Transplantation (Renal), spanning intravesical therapy sequencing, vesicoureteral reflux prophylaxis, pediatric neurogenic bladder pharmacology, recurrent UTI management, and transplant immunosuppression pharmacology
Complete: Head & Neck, Dermatologic, and Asthma & Related Lung Disease, spanning guideline-threshold combination therapy in allergic rhinitis, JAK inhibitor and dupilumab decisions in atopic dermatitis, chronic urticaria and angioedema management, allergic-versus-eosinophilic biologic selection in asthma, and hypersensitivity lung disease pharmacology
Complete: Food & Drug Allergy, Eosinophilic/GI Disorders, and Mast Cell, Anaphylaxis and Other Hypersensitivity, spanning peanut and multi-food oral immunotherapy, eosinophilic esophagitis therapy selection, idiopathic anaphylaxis prophylaxis, systemic mastocytosis, and beta-blocker-refractory anaphylaxis management
Complete: Primary Immunodeficiencies, Immune Hypersensitivity Disorders, and Non-Disease-Specific Pharmacology/Therapeutics, spanning X-linked SCID gene therapy, colchicine-resistant FMF, VEXAS syndrome, drug desensitization protocols, perioperative biologic management, and immunotherapy access and safety