- "Diabetic nephropathy , a common
sequela of diabetes mellitus, is manifested as
severe arteriolar nephrosclerosis,
glomerulosclerosis, and acute or chronic
pyelonephritis. Diabetic glomerulosclerosis is
shown in this slide. This glomerulosclerosis
causes proteinuria in 55% of juvenile onset and
30% of adult onset diabetics. It usually presents
about 16 years after the onset of diabetes.
Diabetic glomerulosclerosis is the result of
thickening of the basement membrane of the
glomerular capillaries and increased cellularity
of the mesangium, along with an increase in the
mesangial matrix. The depostion of basement
membrane in the mesangial matrix may become so
pronounced as to form large nodules of hyaline
material and is referred to as Kimmelstiel-Wilson
disease which is specific for diabetes mellitus.
This specimen shows the Kimmelstiel-Wilson
variant of glomerulosclerosis. Note the large
hyaline mass in the upper left hand portion of
the screen and a smaller one in the center of the
specimen. "
- Image Source: The Urbana Atlas of
Pathology,University of Illinois College of
Medicine at Urbana-Champaign Legends by Patricia
J. O'Morchoe, M.D. Images from material collected
by Donald R. Thursh, M.D. Concept and Design by
Allan H. Levy, M.D., with the assistance of Ms.
Jill Conway.(used with permission)
|
