- " Action of
Thyrotrophin-releasing hormone (TRH) on the
thyrotroph (TSH producing cell in pituitary). TRH
binds to membrane receptors which are coupled to
several enzymes by G proteins (Gp). The G protein
stimulates a series of reactions which causes the
activation of protein kinase (PKC) as well as
causing the mobilization of Ca2+ which also activates PKC, which
phosphorylates proteins (P-proteins) causing TSH
secretion and expression of the genes for the
alpha and beta subunits of TSH. "
- courtesy of Robert H.
Parsons, Ph.D., Rensselaer Polytechnic Institute,
used with permission
|
