Thyroid and Antithyroid Drugs

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The medical student should know and be able to discuss:

Main Menu: Thyroid Physiology and Pharmacology

Main Menu
  • Thyroid Physiology and Pharmacology
  • Thyroid Histology
  • Physiological effects of: triiodothyronine (T3) & thyroxine (T4)
  • symptoms associated with hyperthyroidism (thyrotoxicosis) and hypothyroidism
  • Thyroid Hormone synthesis and release:
    • Scheme
    • Antithyroid drug targets

Levothyroxine (T4) Liothyronine (T3) Liotrix
  • Regulation of thyroid function
  • Pharmacokinetics and uses of levothyroxine (T4) and liothyronine (T3)
  • Complications associated with hypothyroidism
  • Antithyroid Drugs
  • Graves' Disease
  • myxedema
  • Thyroid storm
Three Primary Antithyroid Mechanisms
  • decrease production of THs ("goitrogens")
  • decrease tissue responses to THs
  • destroy thyroid gland (surgery or radiation)

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