Medical Pharmacology Chapter 2:
Pharmacokinetic Practice Questions

Choose the correct answer for each question.

Constant Infusion: the infusion rate for Drug X is 150 ug/min; half-life for elimination is 15 hours; ke = 0.046/hr; Vd = 40L: What is the Css?

0.082 ug/ml

4.89 ug/ml

4,89 mg/ml

9.8 ug/ml

0.0489

Constant Infusion: the infusion rate for Drug X is 150 ug/min; half-life for elimination is 15 hours; ke = 0.046/hr; Vd = 12L (volume of the extracellular space): What is the Css?

4.9 ug/ml

9.7 ug/ml

16.2 ug/ml

14.6 ug/ml

20 ug/ml

Constant Infusion: the infusion rate for Drug X is 300 ug/min; half-life for elimination is 15 hours; ke = 0.046/hr; Vd = 40L: What is the Css?

4.9 ug/ml

9.7 ug/ml

16.2 ug/ml

14.6 ug/ml

none of the above

Constant Infusion: the infusion rate for Drug X is 450 ug/min; half-life for elimination is 15 hours; ke = 0.046/hr; Vd = 40L: What is the Css?

4.9 ug/ml

9.7 ug/ml

16.2 ug/ml

14.6 ug/ml

19 ug/ml

Constant Infusion: the infusion rate for Drug X is 300 ug/min; half-life for elimination is 15 hours; ke = 0.046/hr; Vd = 40L: How long does it take to reach 50% of Css?

3 hours

9 hours

15 hours

24 hours

60 hours

Constant Infusion: what would be the infusion rate for Drug X to attain a steady-state concentration of 25 ug/ml?; half-life for elimination is 15 hours; ke = 0.046/hr; Vd = 40L

25 ug/min

300 ug/min

600 ug/min

760 ug/ml

0.019 ug/ml

Constant Infusion: the infusion rate for Drug X is 300 ug/min; half-life for elimination is 15 hours; ke = 0.046/hr; Vd = 40L: How long does it take to reach 90% of Css?