Medical Pharmacology: Pharmacokinetic Practice Questions

Factor(s) that influence "free drug" in a central compartment:
1. Extent of biotransformation
2. Drug absorption
3. Both
4. Neither
Drug excretion and drug absorption are factors that determine free drug in the central compartment.
1. True
2. False
Protein bound drug contribute to the free drug concentration in the central compartment.
1. True
2. False
Factor(s) that are important in describing drug movement and site of action characteristics include/includes:
1. Molecular size
2. Degree of drug ionization
3. Both
4. Neither
The basic barrier to drug movement:
1. Layers of cells + extracellular proteins such as skin.
2. The cell plasma membrane
3. Intestinal epithelium
Concerning the cellular plasma membrane, choose the correct statement/statements:
1. Plasma membrane composed of an amphipathic lipid bilayer.
2. haracteristics ofC the plasma membrane include high electrical resistance and low permeability to highly polar drug molecules.
3. Both
4. Neither
Which one of the following would be principally a pharmacodynamic rather than a pharmacokinetic characteristic?
1. Clinical response
2. Drug concentration in the systemic circulation
3. Drug tissue distribution
4. None of the above
The optimal drug concentration or target concentration may be thought of as a balance between adverse and beneficial drug effects.
1. True
2. False
Which one or ones of the following are considered basic pharmacokinetic parameters?
1. Volume of distribution
2. Clearance
3. Both
4. Neither
Smallest body volume is associated with this compartment.
1. Total body water
2. Plasma
3. Extracellular water
4. All of the above are about the same.