Medical Pharmacology: Histamine and Bradykinin
Practice Questions
Click on the correct answer.
1 / 10
H2-histamine receptor antagonists were effective in managing acid-peptic disease because H2 receptor blockers inhibited the proton pump.
- True
- False
Site of action for H2 receptor antagonists with respect to acid production inhibition:
- Parietal cells
- Chromaffin cells
- Mast cells
Choose the correct statement(s) concerning H2 receptor antagonists:
- H2 receptor antagonists typically suppress gastric secretion for about four hours.
- H2 receptor blockers tend to inhibit gastric secretion by about 25%.
- Both
- Neither
Which one(s) of the following agents are classified as H2 histamine receptor antagonists?
- Chlorpheniramine
- Ranitidine
- Both
- Neither
Which one(s) is/are (an) example(s) of (an) H2 histamine receptor antagonist(s)?
- Cimetidine
- Ranitidine
- Both
- Neither
Choose the most potent H2-histamine receptor antagonists compared to cimetidine (least potent):
- Ranitidine
- Nizatidine
- Famotidine
Cimetidine, famotidine, and ranitidine undergo first pass, liver metabolism parent drug enters the systemic circulation.
- True
- False
The bioavailability of ranitidine is estimated at about 50% of the oral dose..
- True
- False
This age to-histamine receptor blocker, compared to the others listed, exhibit minimal first-pass hepatic metabolism.
- Nizatidine
- Cimetidine
- Ranitidine
- Amantidine
H2-histamine antagonists dosing may require reduction in patients exhibiting either renal (moderate to severe) or liver (severe) insufficiency.
- True
- False
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