Medical Pharmacology: Hypothalamic and Pituitary Practice Questions

Thyrotropin-releasing hormone (TRH) infusion causes
1. stimulation of prolactin release by the pituitary
2. inhibition of thyroxine production
3. stimulation of ACTH production by the pituitary
4. stimulation of growth hormone production
5. all of the above
Serum thyrotropin levels in hyperthyroidism:
1. enhanced
2. suppressed
TSH fails to rise after TRH administration: this clinical condition is most likely:
1. primary hyperthyroidism
2. secondary (pituitary) hypothyroidism
3. both
4. neither
Unusual pituitary tumor cell responses to TRH may result in:
1. acromegaly
2. Cushing's disease
3. prolactin release failure
4. none of the above
5. A, B & C
Thyroid-stimulating hormone (thyrotropin, TSH) is synthesized at this site:
1. hypothalamus
2. anterior pituitary
TSH subunit that confers thyroid specificity:
1. alpha
2. beta
3. both
4. neither
Mechanism of thyrotropin action -- results in ultimately increased thyroid hormone production:
1. activation of thyroid cell IP3 system
2. activation of guanylyl cyclase system
3. activation of adenylyl cyclase system
4. blockade of beta adrenergic receptors
5. through alpha adrenergic receptor antagonism
Primary thyrotropin (TSH) degradation site:
1. liver
2. kidney
3. excreted unchanged; no degradation
Hypothalamic hormone causing pituitary release of beta-endorphins and ACTH:
1. TRH
2. TSH
3. CRH
4. adrenocorticotropin
ACTH adrenocortical stimulation results in:
1. cholesterol esterases activity
2. reduced mineralocorticoid production
3. adrenal atrophy
4. skin depigmentation