Medical Pharmacology: Immunopharmacology and Janus kinase Inhibitors (JAK Inhibitors)

 

"Rituximab mechanisms of action"
  • Legend: "Rituximab mechanisms of action; the three major independent mechanisms are (1) antibody dependent cellular cytotoxicity (ADCC), (2) complement mediated cytotoxicity (CMC), and (3) apoptosis."

  • Attribution: Seyfizadeh, N., et al., A molecular perspective on rituximab: A monoclonal antibody for B cell non Hodgkin lymphoma and other affections. Critical Reviews in Oncology / Hematology. 97: p. 275-290., CC BY 2.5 <https://creativecommons.org/licenses/by/2.5>, via Wikimedia Commons

 

Rituximab (Rituxan)

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Previous Immunopharmacology Practice Question Set

 

  • Source Material:

    • Rothlin C Gutkind J Chapter 39 Immunosuppressants, Immunomodulation and Tolerance In Goodman & Gilman's The Pharmacological Basis of Therapeutics (Brunton LL Knollman BC eds) McGraw Hill LLC (2023).

    • Rituximab https://en.wikipedia.org/wiki/Rituximab

    • Hanif N Anwer F StatPearls https://www.ncbi.nlm.nih.gov/books/NBK564374/

    • Lake D & Briggs A Ch 55 Immunopharmacology in Katzung's Basic & Clinical Pharmacology (Vanderah TW, ed) 16e McGraw Hill 2023.

    • Wellstein A Atkins M Chapter 72 Antibodies, CAR T Cells, and Proteins to Treat Cancer 14 e In Goodman & Gilman's The Pharmacological Basis of Therapeutics (Brunton LL Knollman BC eds) McGraw Hill LLC (2023)

    • Kafaja T Anwar S Furst D Ch 36 Non Steroidal Anti-Inflammatory Drugs, Disease-Modifiying Antirheumatic Drugs, Nonopioid Analgesics, & Drugs Used in Gout Katzung's Basic & Clinical Pharmacology (Vanderah TW, ed) 16e McGraw Hill 2023.

    • Brezinski E Klickstein L Armstrong A Ch 46 Pharmacology of Immunosuppression in Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy. (Golan DE Armstrong EJ Armstrong AW, eds) 4e 2017

    • Ritter JM Flower R Henderson G Loke YK MacEwan D Robinson E Fullerton J Ch 25 Anti-inflammatory and Immunosuppressant Drugs Rang & Dale's Pharmacology 10e Elsevier 2024.

    • Burchum J Rosenthal L Lehne's Pharmacology for Nursing Care Ch 72 Immunosuppressants Elsevier 2022.

    • Burchum J Rosenthal L Lehne's Pharmacology for Nursing Care Ch 75 Glucocorticoids in Nonendrocrine Disorders Elsevier 2022.

    • Burchum J Rosenthal L Lehne's Pharmacology for Nursing Care Ch 76 Drug Therapy for Rheumatoid Arthritis Elsevier 2022.

    • Bass A Rogatsky Ch 32 Immunomodulatory Drugs in Goldman-Cecil Medicine (Goldman L Schafer, eds) Elsevier 26e 2020

    • Leiva M Takemoto Ch 238 Immunosuppressants in Lippincott Illustrated Reviews: Pharmacology 8e ((Walen et al, eds) Wolters Kluwer 2023.

    • Hall J Hall M Ch 78 Adrenocortical Hormones Guyton and Hall Textbook of Medical Physiology 14e Elsevier 2021.

    • Waller DG Sampson A Hitchings Ch 38 The Immune Response and Immunosuppressant Drugs  Medical Pharmacology & Therapeutics 6e Elsevier 2022

    • Waller DG Sampson A Hitchings Ch 30 Rheumotoid Arthritis, Other Inflammatory Arthrides and Osteoarthritis Medical Pharmacology & Therapeutics 6e Elsevier 2022