Later that year, this patient is
admitted to the hospital for a gram-negative
pneumonia.
He is started on cefazolin (Ancef,
Defzol) 1 gm IV every 6 hours and gentamicin 90
mg IV every 8 hours.
His pneumonia starts to clear, but
6 days later, his creatinine has risen from 5 to
10 and his urine now contains numerous granular
casts.
What has happened? Were the
antibiotics and doses chosen appropriate for the patient? What
were other antibiotic choices and how should the doses be
adjusted for this patients renal dysfunction?
