case continues:
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Later that same year, this patient's gout flares. He is seen in the emergency department and is given colchicine, allopurinol (Zyloprim, Purinol), and ibuprofen. One week later, he comes to see you for his routine followup. At that time, his BP has risen to 180/100 mm Hg, his serum creatinine has risen to 4.3 mg/dL and his WBC count has fallen to 1300.
What has happened? How did drugs contribute to the problem? What could have been done to avoid this problem?