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Nursing Pharmacology Practice Questions: Antifungal Drugs
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amphotericin B cryptococcal meningitis CSF cytochrome P450 drug intrathecal oral
Fluconazole is noted, among azoles, for its good
penetration. Its water solubility allows not only for i.v. administration but also accounts for good bioavailability by the
route of administration. Drug-drug interactions are less common with fluconazole because it interacts less with the
metabolizing system. It is the drug of choice for treating
. I.V. fluconazole has been show to be equivalent to
in management of candidemia in the ICU setting, assuming that the patient has normal white cell blood counts. Oral high-dose fluconazole may be often be an effective replacement for
amphotericin B route of administration for treating
.
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