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Disopyramide [di so peer' a mide]
(Class I Channel Blocker)
  •   Electrophysiological effects similar to quinidine

  • Prescribed to maintain normal sinus rhythm in patients prone to atrial fibrillation and flutter and is also used to prevent ventricular fibrillation or tachycardia.

  • Adverse side-effect profile

  •   Different from qunidine's in that disopyramide is not an alpha-adrenergic receptor blocker but is anti-vagal.

  • Depresses contractility which may lead to congestive heart failure

  •  can cause torsades de pointes, a ventricular arrhythmia