Nursing Pharmacology General Principles Practice Questions

Definition: Therapeutic Index
1. ED50/LD50
2. potency/selectivity
3. EC50/LD50
4. TD50/ED50
5. ED50
Most common drug permeation mechanism:
1. passive diffusion in aqueous or lipid medium
2. active transport
Most likely to be transportred into cells by endocytosis:
1. propranolol
2. iron-complex with its binding protein
3. erythromycin-macrolide antibiotic
4. phenylalanine
5. peptide
Driving force for passive flux of molecules down a concentration gradient:
1. area/thickness
2. difference in concentration
3. permeability coefficient
4. area x permeability coefficient/thickness
5. thickness
Weak base:
1. neutral molecule that dissociates into an anion and a proton
2. neutral molecule that forms a cation upon combining with a proton
3. charged molecule that remains charged independent upon pH
4. neutral molecule that remains uncharged independent of pH
5. none of the above
Elaboration of vesicular content (neurotransmitter) into the synaptic cleft is an example of:
1. carrier transport
2. passive diffusion
3. endocytosis
4. exocytosis
5. lipid diffusion
Lipid solubility and drugs:
1. more of the weak acid drug will be in the lipid-soluble form at alkaline pH.
2. more of the weak acid drug will be in the lipid soluble form at acid pH.
3. more of the weak base drug will be in the lipid soluble form at alkaline pH
4. A & C
5. B & C
Ion-trapping in the kidney:
1. Weak acids are usually excreted slower in alkaline urine
2. Weak bases are usually excreted faster in acidic urine
3. both
4. neither
Permanently charged amine:
1. primary amine
2. secondary amine
3. tertiary amine
4. quaternary amine
Most acidic
1. urine
2. breast milk
3. jejunum,ileum contents
4. stomach contents
5. vaginal secretions