Thyroid hormone more likely to be completely absorbed following oral administration:

Effective hyperthyroidism on thyroxine (T4) metabolic clearance:

Example(s) of (a) drug(s) that increases metabolism of T4 and T3:

Inhibition of pituitary TSH release:

Inhibition of thyroid hormone synthesis or release:

Associated with 5'-deiodinase inhibition:

Associated with increased TBG (thyroxine-binding globulin):

Eyes: periorbital edema; exophthalmos; wide stare:

Respiratory system: decreased vital capacity; dyspnea

CNS: lethargy; neuropathy

Reproductive system: hypermenorrhea; oligospermia; decreased enamel steroid metabolism

Gastrointestinal system: increased appetite; hypoproteinemia

Skin: pale, cool

Inhibits iodide transport into thyroid gland:

More potent thyroid hormone:

Displacement of thyroid hormones (thyroxine, triiodothyronine) from TBG; may cause hyperthyroxinemia:

Preparation of choice for thyroid replacement.

Inhibits conversion T4 to T3 in the liver, kidney, pituitary gland, brain;may be useful in treating hyperthyroidism; routinely used as a radiographic contrast agent

Thioamide less likely to cross the placental barrier:

Competitive inhibition of iodide uptake by the thyroid: