Chapter 3:  General Principles: Pharmacodynamics

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Bourne, H.R. Drug Receptors and Pharmacodynamics, in Basic and Clinical Pharmacology, (Katzung, B. G., ed) Appleton-Lange, 1998, pp 9-33.

Ross, E.M. Pharmacodynamics In, Goodman and Gillman's The Pharmacologial Basis of Therapeutics,(Hardman, J.G, Limbird, L.E, Molinoff, P.B., Ruddon, R.W, and Gilman, A.G.,eds) TheMcGraw-Hill Companies, Inc.,1996, pp. 29 -41.

Bourne, H.R. Drug Receptors and Pharmacodynamics, in Basic and Clinical Pharmacology, (Katzung, B. G., ed) Appleton-Lange, 1998, pp 9-33

Bourne, H.R. Drug Receptors and Pharmacodynamics, in Basic and Clinical Pharmacology,(Katzung, B. G., ed) Appleton-Lange, 1998, pp 9-33.

Ross, Elliott M.: Pharmacodynamics: mechanisms of Drug Action and the Relationship Between Drug Concentration and Effect: In, Goodman and Gillman's The Pharmacologial Basis of Therapeutics,(Hardman, J.G, Limbird, L.E, Molinoff, P.B., Ruddon, R.W, and Gilman, A.G.,eds) The McGraw-Hill Companies, Inc.,1996, pp.29 - 35.

Hoffman, B. B. Adrenoceptor-Activating & Other Sympathomimetic Drugs: in Basic and Clinical Pharmacology, (Katzung, B. G., ed) Appleton-Lange, 1998, p.118-122.

Pappano, A.J. Cholinoceptor-Activating & Cholinesterase-Inhibiting Drugs, In Basic and Clinical Pharmacology, 7th Edition, (Katzung, B.G.,ed) Appleton & Lange, 1998, p. 93-94

Bourne, H.R. Drug Receptors and Pharmacodynamics, in Basic and Clinical Pharmacology,(Katzung, B. G., ed) Appleton-Lange, 1998, pp 9-33

 

Lefkowitz, R.J, Hoffman, B.B and Taylor, P. Neurotransmission: The Autonomic and Somatic Motor Nervous Systems, In, Goodman and Gillman's The Pharmacologial Basis of Therapeutics,(Hardman, J.G, Limbird, L.E, Molinoff, P.B., Ruddon, R.W, and Gilman, A.G.,eds) TheMcGraw-Hill Companies, Inc.,1996, pp.112-137.

Hoffman, B. B. Adrenoceptor-Activating & Other Sympathomimetic Drugs:  in Basic and Clinical Pharmacology, (Katzung, B. G., ed) Appleton-Lange, 1998, p.118-122.

Graded Dose-Response Curve

Graded dose-response curves (plotted directly (no log transform) often resemble a Michaelis-Menten curves in which substrate (x-axis) is plotted against reaction velocity (y-axis)

Factors that result in variation in drug responsiveness
  • Idiosyncratic drug response
  • Tachyphylactic response
  • Hypersensitivity response
  • Alteration in concentration of drug that reaches the receptor (pharmacokinetic effect)
  • Variation in endogenous receptor ligand concentration
  • Alteration in the number or function of receptors
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