1. Meltzer HY (1989). The ratios of serotonin2 and dopamine2 affinities differentiate atypical and typical antipsychotic drugs. Psychopharmacol Bull. 25(3):390–392. PMID: 2576319

2. Kapur S, Seeman P (2001). Does fast dissociation from the dopamine D2 receptor explain the action of atypical antipsychotics? A new hypothesis. Am J Psychiatry. 158(3):360–369. PMID: 11229973

3. Burris KD, Molski TF, Xu C, et al. (2002). Aripiprazole, a novel antipsychotic, is a high-affinity partial agonist at human dopamine D2 receptors. J Pharmacol Exp Ther. 302(1):381–389. PMID: 12065741

4. Kane J, Honigfeld G, Singer J, Meltzer H (1988). Clozapine for the treatment-resistant schizophrenic: a double-blind comparison with chlorpromazine. Arch Gen Psychiatry. 45(9):789–796. PMID: 3046553

5. Alvir JM, Lieberman JA, Safferman AZ, Schwimmer JL, Schaaf JA (1993). Clozapine-induced agranulocytosis: incidence and risk factors in the United States. N Engl J Med. 329(3):162–167. PMID: 8515788

6. Meltzer HY, Alphs L, Green AI, et al. (2003). Clozapine treatment for suicidality in schizophrenia: International Suicide Prevention Trial (InterSePT). Arch Gen Psychiatry. 60(1):82–91. PMID: 12511175

7. American Diabetes Association; American Psychiatric Association; American Association of Clinical Endocrinologists; North American Association for the Study of Obesity (2004). Consensus development conference on antipsychotic drugs and obesity and diabetes. Diabetes Care. 27(2):596–601. PMID: 14747245

8. Newcomer JW (2005). Second-generation (atypical) antipsychotics and metabolic effects: a comprehensive literature review. CNS Drugs. 19(Suppl 1):1–93. PMID: 15998156

9. Jones PB, Barnes TR, Davies L, et al. (2006). Randomized controlled trial of the effect on quality of life of second- vs first-generation antipsychotic drugs in schizophrenia: CUtLASS 1. Arch Gen Psychiatry. 63(10):1079–1087. PMID: 17015810

10. Lieberman JA, Stroup TS, McEvoy JP, et al. (2005). Effectiveness of antipsychotic drugs in patients with chronic schizophrenia (CATIE). N Engl J Med. 353(12):1209–1223. PMID: 16172203

11. Leucht S, Corves C, Arbter D, Engel RR, Li C, Davis JM (2009). Second-generation versus first-generation antipsychotic drugs for schizophrenia: a meta-analysis. Lancet. 373(9657):31–41. PMID: 19058842

12. Leucht S, Cipriani A, Spineli L, et al. (2013). Comparative efficacy and tolerability of 15 antipsychotic drugs in schizophrenia: a multiple-treatments meta-analysis. Lancet. 382(9896):951–962. PMID: 23810019

13. Huhn M, Nikolakopoulou A, Schneider-Thoma J, et al. (2019). Comparative efficacy and tolerability of 32 oral antipsychotics for the acute treatment of adults with multi-episode schizophrenia: a systematic review and network meta-analysis. Lancet. 394(10202):939–951. PMID: 31303314

14. Kishimoto T, Hagi K, Nitta M, et al. (2018). Effectiveness of long-acting injectable vs oral antipsychotics in patients with schizophrenia: a meta-analysis of prospective and retrospective cohort studies. Schizophr Bull. 44(3):603–619. PMID: 29868849

15. Keepers GA, Fochtmann LJ, Anzia JM, et al. (2020). The American Psychiatric Association Practice Guideline for the Treatment of Patients with Schizophrenia. Am J Psychiatry. 177(9):868–872. PMID: 32867516

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