Clinical Cases  ·  Allergy and Immunology Vol. II  ·  Eosinophilic/GI Disorders
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Allergy and Immunology

Eosinophilic/GI Disorders

12 cases on eosinophilic esophagitis first-line therapy selection, allergy-testing-directed versus empiric elimination diets, maintenance de-escalation after remission, hypereosinophilic syndrome (FIP1L1-PDGFRA-positive and -negative) therapy selection, eosinophilic gastroenteritis, EoE with comorbid celiac disease or Crohn's disease, food protein-induced allergic proctocolitis, FDA-approved versus compounded topical steroid formulations, the retired PPI-trial requirement, and elemental formula versus elimination diet in pediatric failure to thrive — choose a case below to open its full multi-voice debate.

Allergy and ImmunologyEosinophilic/GI Disorders
First-Line Eosinophilic Esophagitis: A Guideline Written Before One of Its Options Existed

Eosinophilic Esophagitis: A single patient, newly diagnosed after a food-impaction visit. The disagreement isn't about which therapy works — it's about...

Case 0001
Allergy and ImmunologyEosinophilic/GI Disorders
A Long Skin-Test Panel and a Question of What It's Actually Worth in EoE

Eosinophilic Esophagitis: A single patient with eight positive skin tests and a diagnosis those tests weren't built to guide. The disagreement is...

Case 0002
Allergy and ImmunologyEosinophilic/GI Disorders
Two Years of Remission and a Question of How Long Is Long Enough

Eosinophilic Esophagitis: A single patient in sustained histologic remission, asking to stop the twice-daily regimen that got her there. The...

Case 0003
Allergy and ImmunologyEosinophilic/GI Disorders
Hypereosinophilic Syndrome and a Fusion Gene Result That Hasn't Come Back Yet

Hypereosinophilic Syndrome: A single patient with eosinophil counts and organ findings that fit one diagnosis strongly, confirmed by nothing yet. The...

Case 0004
Allergy and ImmunologyEosinophilic/GI Disorders
Steroid-Sparing in Hypereosinophilic Syndrome: A Trial That Almost Fits Her

Hypereosinophilic Syndrome (FIP1L1-PDGFRA-Negative): A single patient who needs off steroids and doesn't quite meet the entry criteria of the trial...

Case 0005
Allergy and ImmunologyEosinophilic/GI Disorders
Eosinophilic Gastroenteritis Without a Trial to Guide Any of It

Eosinophilic Gastroenteritis (Non-Esophageal): A single patient with a rare, under-studied diagnosis and a family history that makes her want to avoid...

Case 0006
Allergy and ImmunologyEosinophilic/GI Disorders
Celiac Disease in Remission, and an Esophagus That Didn't Get the Message

Eosinophilic Esophagitis with Comorbid Celiac Disease: A single patient whose celiac disease is objectively controlled and whose esophagus is inflamed...

Case 0007
Allergy and ImmunologyEosinophilic/GI Disorders
Blood in a Thriving Infant's Diaper, and How Much Should Change Because of It

Food Protein-Induced Allergic Proctocolitis: A single patient, six weeks old, gaining weight well, with blood in her stool that's almost certainly...

Case 0008
Allergy and ImmunologyEosinophilic/GI Disorders
One Biologic Decision, Two Diseases Both Wanting to Go First

Eosinophilic Esophagitis with Comorbid Crohn's Disease: A single patient with an active Crohn's flare and a newly diagnosed eosinophilic esophagitis,...

Case 0009
Allergy and ImmunologyEosinophilic/GI Disorders
An FDA-Approved Option for a Use Its Own Trials Never Tested

Eosinophilic Esophagitis: A single patient stable for years on a compounded regimen her insurer now wants replaced with the newly approved version of...

Case 0010
Allergy and ImmunologyEosinophilic/GI Disorders
A Diagnostic Rule That Guidelines Retired, Still Shaping a Treatment Decision

Eosinophilic Esophagitis: A single patient newly diagnosed with EoE after a second food-impaction visit. The disagreement isn't about whether a PPI...

Case 0011
Allergy and ImmunologyEosinophilic/GI Disorders
Failure to Thrive in a Toddler With Eosinophilic Esophagitis, and Two Ways to Fix It

Eosinophilic Esophagitis: A single patient, three years old, falling off his growth curve with a new EoE diagnosis and early feeding aversion. The...

Case 0012
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